Focal adhesion kinase activation limits efficacy of Dasatinib in c‐Myc driven hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options. Recently, it was found that Dasatinib treatment led to synthetic lethality in c‐Myc high‐expressing human cancer cells due to inhibition of p‐Lyn. Overexpression of c‐Myc is frequently seen in human HCC. We investi...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xianqiong, Song, Xinhua, Zhang, Jie, Xu, Zhong, Che, Li, Qiao, Yu, Ortiz Pedraza, Yunuen, Cigliano, Antonio, Pascale, Rosa M., Calvisi, Diego F., Liu, Yanju, Chen, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308083/
https://www.ncbi.nlm.nih.gov/pubmed/30370649
http://dx.doi.org/10.1002/cam4.1777

Ejemplares similares

Ejemplares similares