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Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia

BACKGROUND AND AIMS: There have been few reports on lactase deficiency (LD) and lactose intolerance (LI) in Malaysia, which has a peculiar mix of three distinct major Asian races—Malay, Chinese, and Indian. The aim of this study was to determine the prevalence of LD and LI in a young multiethnic Mal...

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Autores principales: Goh, Li‐Han, Mohd Said, Rosaida, Goh, Khean‐Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308090/
https://www.ncbi.nlm.nih.gov/pubmed/30619942
http://dx.doi.org/10.1002/jgh3.12089
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author Goh, Li‐Han
Mohd Said, Rosaida
Goh, Khean‐Lee
author_facet Goh, Li‐Han
Mohd Said, Rosaida
Goh, Khean‐Lee
author_sort Goh, Li‐Han
collection PubMed
description BACKGROUND AND AIMS: There have been few reports on lactase deficiency (LD) and lactose intolerance (LI) in Malaysia, which has a peculiar mix of three distinct major Asian races—Malay, Chinese, and Indian. The aim of this study was to determine the prevalence of LD and LI in a young multiethnic Malaysian population. METHODS: Lactase activity was measured with a (13)CO(2) lactose breath test using an infrared spectrometer. Each subject took 25 g of lactose naturally enriched in (13)CO(2) together with 250 mL of water after an overnight fast. Breath samples were collected at baseline and at 15‐min intervals for 180 min. Subjects were asked to report gastrointestinal (GI) symptoms following ingestion of the lactose test meal. RESULTS: Of the 248 subjects tested, 216 (87.1%) were lactase deficient. We found no significant differences in the presentation of LD between gender and races. LD was found in 87.5% of males and 86.8% of females (P = 0.975) and in different races: Chinese (88.5%) versus Malay (83.1%) (P = 0.399), Indian (90.5%) versus Malay (P = 0.295), and Chinese versus Indian (P = 0.902). LI was diagnosed in only 49 (19.8%) subjects; 35 patients had diarrhea, while the remainder had at least two other GI symptoms after the lactose meal. CONCLUSION: The prevalence of LD was high in all three major ethnic groups—Malays, Chinese, and Indians. Ironically, the prevalence of LI was low overall.
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spelling pubmed-63080902019-01-07 Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia Goh, Li‐Han Mohd Said, Rosaida Goh, Khean‐Lee JGH Open Original Articles BACKGROUND AND AIMS: There have been few reports on lactase deficiency (LD) and lactose intolerance (LI) in Malaysia, which has a peculiar mix of three distinct major Asian races—Malay, Chinese, and Indian. The aim of this study was to determine the prevalence of LD and LI in a young multiethnic Malaysian population. METHODS: Lactase activity was measured with a (13)CO(2) lactose breath test using an infrared spectrometer. Each subject took 25 g of lactose naturally enriched in (13)CO(2) together with 250 mL of water after an overnight fast. Breath samples were collected at baseline and at 15‐min intervals for 180 min. Subjects were asked to report gastrointestinal (GI) symptoms following ingestion of the lactose test meal. RESULTS: Of the 248 subjects tested, 216 (87.1%) were lactase deficient. We found no significant differences in the presentation of LD between gender and races. LD was found in 87.5% of males and 86.8% of females (P = 0.975) and in different races: Chinese (88.5%) versus Malay (83.1%) (P = 0.399), Indian (90.5%) versus Malay (P = 0.295), and Chinese versus Indian (P = 0.902). LI was diagnosed in only 49 (19.8%) subjects; 35 patients had diarrhea, while the remainder had at least two other GI symptoms after the lactose meal. CONCLUSION: The prevalence of LD was high in all three major ethnic groups—Malays, Chinese, and Indians. Ironically, the prevalence of LI was low overall. Wiley Publishing Asia Pty Ltd 2018-09-19 /pmc/articles/PMC6308090/ /pubmed/30619942 http://dx.doi.org/10.1002/jgh3.12089 Text en © 2018 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Goh, Li‐Han
Mohd Said, Rosaida
Goh, Khean‐Lee
Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title_full Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title_fullStr Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title_full_unstemmed Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title_short Lactase deficiency and lactose intolerance in a multiracial Asian population in Malaysia
title_sort lactase deficiency and lactose intolerance in a multiracial asian population in malaysia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308090/
https://www.ncbi.nlm.nih.gov/pubmed/30619942
http://dx.doi.org/10.1002/jgh3.12089
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