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Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality

Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metab...

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Autores principales: Schmitt, Andrea, Maurus, Isabel, Rossner, Moritz J., Röh, Astrid, Lembeck, Moritz, von Wilmsdorff, Martina, Takahashi, Shun, Rauchmann, Boris, Keeser, Daniel, Hasan, Alkomiet, Malchow, Berend, Falkai, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308154/
https://www.ncbi.nlm.nih.gov/pubmed/30622486
http://dx.doi.org/10.3389/fpsyt.2018.00690
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author Schmitt, Andrea
Maurus, Isabel
Rossner, Moritz J.
Röh, Astrid
Lembeck, Moritz
von Wilmsdorff, Martina
Takahashi, Shun
Rauchmann, Boris
Keeser, Daniel
Hasan, Alkomiet
Malchow, Berend
Falkai, Peter
author_facet Schmitt, Andrea
Maurus, Isabel
Rossner, Moritz J.
Röh, Astrid
Lembeck, Moritz
von Wilmsdorff, Martina
Takahashi, Shun
Rauchmann, Boris
Keeser, Daniel
Hasan, Alkomiet
Malchow, Berend
Falkai, Peter
author_sort Schmitt, Andrea
collection PubMed
description Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metabolic syndrome is a risk factor for cardiovascular diseases, and the risk of these diseases is 2- to 3-fold higher in schizophrenia patients than in the general population. The suicide risk is also higher in schizophrenia, partly as a result of depression, positive, and cognitive symptoms of the disease. The higher suicide rate and higher rate of cardiac mortality, a consequence of the increased prevalance of cardiovascular diseases, contribute to the reduced life expectancy, which is up to 20 years lower than in the general population. Regular physical activity, especially in combination with psychosocial and dietary interventions, can improve parameters of the metabolic syndrome and cardiorespiratory fitness. Furthermore, aerobic exercise has been shown to improve cognitive deficits; total symptom severity, including positive and negative symptoms; depression; quality of life; and global functioning. High-intensity interval endurance training is a feasible and effective way to improve cardiorespiratory fitness and metabolic parameters and has been established as such in somatic disorders. It may have more beneficial effects on the metabolic state than more moderate and continuous endurance training methods, but to date it has not been investigated in schizophrenia patients in controlled, randomized trials. This review discusses physical training methods to improve cardiorespiratory fitness and reduce metabolic syndrome risk factors and symptoms in schizophrenia patients. The results of studies and future high-quality clinical trials are expected to lead to the development of an evidence-based physical training program for patients that includes practical recommendations, such as the optimal length and type of aerobic exercise programs and the ideal combination of exercise, psychoeducation, and individual weight management sessions.
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spelling pubmed-63081542019-01-08 Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality Schmitt, Andrea Maurus, Isabel Rossner, Moritz J. Röh, Astrid Lembeck, Moritz von Wilmsdorff, Martina Takahashi, Shun Rauchmann, Boris Keeser, Daniel Hasan, Alkomiet Malchow, Berend Falkai, Peter Front Psychiatry Psychiatry Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metabolic syndrome is a risk factor for cardiovascular diseases, and the risk of these diseases is 2- to 3-fold higher in schizophrenia patients than in the general population. The suicide risk is also higher in schizophrenia, partly as a result of depression, positive, and cognitive symptoms of the disease. The higher suicide rate and higher rate of cardiac mortality, a consequence of the increased prevalance of cardiovascular diseases, contribute to the reduced life expectancy, which is up to 20 years lower than in the general population. Regular physical activity, especially in combination with psychosocial and dietary interventions, can improve parameters of the metabolic syndrome and cardiorespiratory fitness. Furthermore, aerobic exercise has been shown to improve cognitive deficits; total symptom severity, including positive and negative symptoms; depression; quality of life; and global functioning. High-intensity interval endurance training is a feasible and effective way to improve cardiorespiratory fitness and metabolic parameters and has been established as such in somatic disorders. It may have more beneficial effects on the metabolic state than more moderate and continuous endurance training methods, but to date it has not been investigated in schizophrenia patients in controlled, randomized trials. This review discusses physical training methods to improve cardiorespiratory fitness and reduce metabolic syndrome risk factors and symptoms in schizophrenia patients. The results of studies and future high-quality clinical trials are expected to lead to the development of an evidence-based physical training program for patients that includes practical recommendations, such as the optimal length and type of aerobic exercise programs and the ideal combination of exercise, psychoeducation, and individual weight management sessions. Frontiers Media S.A. 2018-12-21 /pmc/articles/PMC6308154/ /pubmed/30622486 http://dx.doi.org/10.3389/fpsyt.2018.00690 Text en Copyright © 2018 Schmitt, Maurus, Rossner, Röh, Lembeck, von Wilmsdorff, Takahashi, Rauchmann, Keeser, Hasan, Malchow and Falkai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Schmitt, Andrea
Maurus, Isabel
Rossner, Moritz J.
Röh, Astrid
Lembeck, Moritz
von Wilmsdorff, Martina
Takahashi, Shun
Rauchmann, Boris
Keeser, Daniel
Hasan, Alkomiet
Malchow, Berend
Falkai, Peter
Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title_full Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title_fullStr Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title_full_unstemmed Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title_short Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
title_sort effects of aerobic exercise on metabolic syndrome, cardiorespiratory fitness, and symptoms in schizophrenia include decreased mortality
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308154/
https://www.ncbi.nlm.nih.gov/pubmed/30622486
http://dx.doi.org/10.3389/fpsyt.2018.00690
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