A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion

The invasion of Chlamydia trachomatis, an obligate intracellular bacterium, into epithelial cells is driven by a complex interplay of host and bacterial factors. To comprehensively define the host genes required for pathogen invasion, we undertook a fluorescence-activated cell sorting (FACS)-based C...

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Detalles Bibliográficos
Autores principales: Park, Joseph S., Helble, Jennifer D., Lazarus, Jacob E., Yang, Guanhua, Blondel, Carlos J., Doench, John G., Starnbach, Michael N., Waldor, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308251/
https://www.ncbi.nlm.nih.gov/pubmed/30590252
http://dx.doi.org/10.1016/j.isci.2018.12.011

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