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A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4(+) T Cells

Sirtuin 1 (SIRT1) is a critical suppressor of T cell immunity. However, whether SIRT1 is involved in the progression of acute graft-vs.-host disease (aGVHD) has still remained unclear. PI3K/Akt/mTOR pathway is a crucial element involved in the activation and functions of T cells. Over-activation of...

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Detalles Bibliográficos
Autores principales:	Xu, Ya-jing, Chen, Fang-ping, Chen, Yan, Fu, Bin, Liu, En-yi, Zou, Lang, Liu, Lin-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308326/ https://www.ncbi.nlm.nih.gov/pubmed/30622543 http://dx.doi.org/10.3389/fimmu.2018.03078

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