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A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes

The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access vol...

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Autores principales: Cisnal, Ana, Fraile, Juan-Carlos, Pérez-Turiel, Javier, Muñoz-Martinez, Victor, Müller, Carsten, R. Ihmig, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308657/
https://www.ncbi.nlm.nih.gov/pubmed/30486353
http://dx.doi.org/10.3390/s18124152
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author Cisnal, Ana
Fraile, Juan-Carlos
Pérez-Turiel, Javier
Muñoz-Martinez, Victor
Müller, Carsten
R. Ihmig, Frank
author_facet Cisnal, Ana
Fraile, Juan-Carlos
Pérez-Turiel, Javier
Muñoz-Martinez, Victor
Müller, Carsten
R. Ihmig, Frank
author_sort Cisnal, Ana
collection PubMed
description The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage V(a). This paper proposes a method to calculate V(a) that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing.
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spelling pubmed-63086572019-01-04 A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes Cisnal, Ana Fraile, Juan-Carlos Pérez-Turiel, Javier Muñoz-Martinez, Victor Müller, Carsten R. Ihmig, Frank Sensors (Basel) Article The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage V(a). This paper proposes a method to calculate V(a) that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing. MDPI 2018-11-27 /pmc/articles/PMC6308657/ /pubmed/30486353 http://dx.doi.org/10.3390/s18124152 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cisnal, Ana
Fraile, Juan-Carlos
Pérez-Turiel, Javier
Muñoz-Martinez, Victor
Müller, Carsten
R. Ihmig, Frank
A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title_full A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title_fullStr A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title_full_unstemmed A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title_short A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
title_sort measurement setup and automated calculation method to determine the charge injection capacity of implantable microelectrodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308657/
https://www.ncbi.nlm.nih.gov/pubmed/30486353
http://dx.doi.org/10.3390/s18124152
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