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A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes
The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access vol...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308657/ https://www.ncbi.nlm.nih.gov/pubmed/30486353 http://dx.doi.org/10.3390/s18124152 |
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author | Cisnal, Ana Fraile, Juan-Carlos Pérez-Turiel, Javier Muñoz-Martinez, Victor Müller, Carsten R. Ihmig, Frank |
author_facet | Cisnal, Ana Fraile, Juan-Carlos Pérez-Turiel, Javier Muñoz-Martinez, Victor Müller, Carsten R. Ihmig, Frank |
author_sort | Cisnal, Ana |
collection | PubMed |
description | The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage V(a). This paper proposes a method to calculate V(a) that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing. |
format | Online Article Text |
id | pubmed-6308657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63086572019-01-04 A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes Cisnal, Ana Fraile, Juan-Carlos Pérez-Turiel, Javier Muñoz-Martinez, Victor Müller, Carsten R. Ihmig, Frank Sensors (Basel) Article The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage V(a). This paper proposes a method to calculate V(a) that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing. MDPI 2018-11-27 /pmc/articles/PMC6308657/ /pubmed/30486353 http://dx.doi.org/10.3390/s18124152 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cisnal, Ana Fraile, Juan-Carlos Pérez-Turiel, Javier Muñoz-Martinez, Victor Müller, Carsten R. Ihmig, Frank A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title | A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title_full | A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title_fullStr | A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title_full_unstemmed | A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title_short | A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes |
title_sort | measurement setup and automated calculation method to determine the charge injection capacity of implantable microelectrodes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308657/ https://www.ncbi.nlm.nih.gov/pubmed/30486353 http://dx.doi.org/10.3390/s18124152 |
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