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Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes

OBJECTIVES: The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to metabolize MG; however, the relative contribution...

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Detalles Bibliográficos
Autores principales:	Schumacher, Dagmar, Morgenstern, Jakob, Oguchi, Yoko, Volk, Nadine, Kopf, Stefan, Groener, Jan Benedikt, Nawroth, Peter Paul, Fleming, Thomas, Freichel, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308908/ https://www.ncbi.nlm.nih.gov/pubmed/30287091 http://dx.doi.org/10.1016/j.molmet.2018.09.005

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