Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity

OBJECTIVE: Although debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of...

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Detalles Bibliográficos
Autores principales: Gerlini, R., Berti, L., Darr, J., Lassi, M., Brandmaier, S., Fritsche, L., Scheid, F., Böhm, A., Königsrainer, A., Grallert, H., Häring, H.U., Hrabě de Angelis, M., Staiger, H., Teperino, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308911/
https://www.ncbi.nlm.nih.gov/pubmed/30309776
http://dx.doi.org/10.1016/j.molmet.2018.09.004
Descripción
Sumario:OBJECTIVE: Although debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown. METHODS: Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases. RESULTS AND CONCLUSIONS: Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity.

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