Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC microenvironment and can influence tumor progression. This revi...

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Autores principales: Yin, Zeli, Jiang, Keqiu, Li, Rui, Dong, Chengyong, Wang, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309092/
https://www.ncbi.nlm.nih.gov/pubmed/30593276
http://dx.doi.org/10.1186/s12943-018-0926-6
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author Yin, Zeli
Jiang, Keqiu
Li, Rui
Dong, Chengyong
Wang, Liming
author_facet Yin, Zeli
Jiang, Keqiu
Li, Rui
Dong, Chengyong
Wang, Liming
author_sort Yin, Zeli
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC microenvironment and can influence tumor progression. This review discusses MSC migration to liver fibrosis and the HCC microenvironment, MSC involvement in HCC initiation and progression and the widespread application of MSCs in HCC-targeted therapy, thus clarifying the critical roles of MSCs in HCC.
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spelling pubmed-63090922019-01-03 Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy Yin, Zeli Jiang, Keqiu Li, Rui Dong, Chengyong Wang, Liming Mol Cancer Review Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC microenvironment and can influence tumor progression. This review discusses MSC migration to liver fibrosis and the HCC microenvironment, MSC involvement in HCC initiation and progression and the widespread application of MSCs in HCC-targeted therapy, thus clarifying the critical roles of MSCs in HCC. BioMed Central 2018-12-28 /pmc/articles/PMC6309092/ /pubmed/30593276 http://dx.doi.org/10.1186/s12943-018-0926-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yin, Zeli
Jiang, Keqiu
Li, Rui
Dong, Chengyong
Wang, Liming
Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title_full Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title_fullStr Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title_full_unstemmed Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title_short Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
title_sort multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309092/
https://www.ncbi.nlm.nih.gov/pubmed/30593276
http://dx.doi.org/10.1186/s12943-018-0926-6
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