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BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

BACKGROUND: Base Editing is a precise genome editing method that uses a deaminase-Cas9 fusion protein to mutate cytidine to thymidine in target DNA in situ without the generation of a double-strand break. However, the efficient enrichment of genetically modified cells using this technique is limited...

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Detalles Bibliográficos
Autores principales:	Coelho, Matthew A., Li, Songyuan, Pane, Luna Simona, Firth, Mike, Ciotta, Giovanni, Wrigley, Jonathan D., Cuomo, Maria Emanuela, Maresca, Marcello, Taylor, Benjamin J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309101/ https://www.ncbi.nlm.nih.gov/pubmed/30593278 http://dx.doi.org/10.1186/s12915-018-0617-1

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