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Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP

Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3′-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PAPα, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then...

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Autor principal: Laishram, Rakesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309179/
https://www.ncbi.nlm.nih.gov/pubmed/24873880
http://dx.doi.org/10.1016/j.febslet.2014.05.029
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author Laishram, Rakesh S.
author_facet Laishram, Rakesh S.
author_sort Laishram, Rakesh S.
collection PubMed
description Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3′-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PAPα, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulate a select set of mRNAs in the cell. In addition, several non-canonical PAPs have been identified with diverse cellular functions. Further, canonical PAP itself exists in multiple isoforms thus illustrating the diversity of PAPs. In this review, we compare two nuclear PAPs, Star-PAP and PAPα with a general overview of PAP diversity in the cell. Emerging evidence suggests distinct niches of target pre-mRNAs for the two PAPs and that modulation of these PAPs regulates distinct cellular functions.
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spelling pubmed-63091792018-12-28 Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP Laishram, Rakesh S. FEBS Lett Article Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3′-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PAPα, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulate a select set of mRNAs in the cell. In addition, several non-canonical PAPs have been identified with diverse cellular functions. Further, canonical PAP itself exists in multiple isoforms thus illustrating the diversity of PAPs. In this review, we compare two nuclear PAPs, Star-PAP and PAPα with a general overview of PAP diversity in the cell. Emerging evidence suggests distinct niches of target pre-mRNAs for the two PAPs and that modulation of these PAPs regulates distinct cellular functions. 2014-05-27 2014-06-27 /pmc/articles/PMC6309179/ /pubmed/24873880 http://dx.doi.org/10.1016/j.febslet.2014.05.029 Text en http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Article
Laishram, Rakesh S.
Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title_full Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title_fullStr Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title_full_unstemmed Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title_short Poly(A) polymerase (PAP) diversity in gene expression – Star-PAP vs canonical PAP
title_sort poly(a) polymerase (pap) diversity in gene expression – star-pap vs canonical pap
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309179/
https://www.ncbi.nlm.nih.gov/pubmed/24873880
http://dx.doi.org/10.1016/j.febslet.2014.05.029
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