Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population

Genome wide association study has identified rs7025486 G>A polymorphism within DAB2IP (Disabled homolog 2-interacting protein) gene with increased risk of coronary heart disease (CAD). In this study we have determined the frequency and association of rs7025486 with CAD in Indians. The study was p...

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Detalles Bibliográficos
Autores principales: Bhanushali, Aparna A., Pradhan, Gayatri, Contractor, A, Das, Bibhu R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309282/
https://www.ncbi.nlm.nih.gov/pubmed/30595311
http://dx.doi.org/10.1016/j.ihj.2018.06.016
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author Bhanushali, Aparna A.
Pradhan, Gayatri
Contractor, A
Das, Bibhu R.
author_facet Bhanushali, Aparna A.
Pradhan, Gayatri
Contractor, A
Das, Bibhu R.
author_sort Bhanushali, Aparna A.
collection PubMed
description Genome wide association study has identified rs7025486 G>A polymorphism within DAB2IP (Disabled homolog 2-interacting protein) gene with increased risk of coronary heart disease (CAD). In this study we have determined the frequency and association of rs7025486 with CAD in Indians. The study was performed on 214 patients with CAD and 125 controls. The ‘AA’ genotype was associated with an increased risk in the CAD age group <50 yrs as compared to CAD age group>50 yrs (OR 3.149; P 0.034) and controls >50 yrs (OR 3.430; P 0.080). The risk allele (A) was significantly associated with premature CAD.
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spelling pubmed-63092822019-12-01 Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population Bhanushali, Aparna A. Pradhan, Gayatri Contractor, A Das, Bibhu R. Indian Heart J Short Communication Genome wide association study has identified rs7025486 G>A polymorphism within DAB2IP (Disabled homolog 2-interacting protein) gene with increased risk of coronary heart disease (CAD). In this study we have determined the frequency and association of rs7025486 with CAD in Indians. The study was performed on 214 patients with CAD and 125 controls. The ‘AA’ genotype was associated with an increased risk in the CAD age group <50 yrs as compared to CAD age group>50 yrs (OR 3.149; P 0.034) and controls >50 yrs (OR 3.430; P 0.080). The risk allele (A) was significantly associated with premature CAD. Elsevier 2018-12 2018-06-19 /pmc/articles/PMC6309282/ /pubmed/30595311 http://dx.doi.org/10.1016/j.ihj.2018.06.016 Text en © 2018 Published by Elsevier B.V. on behalf of Cardiological Society of India. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Bhanushali, Aparna A.
Pradhan, Gayatri
Contractor, A
Das, Bibhu R.
Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title_full Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title_fullStr Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title_full_unstemmed Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title_short Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population
title_sort frequency and association of disabled homolog 2-interacting protein (dab2ip) variant rs7025486 g>a with coronary artery disease risk in indian population
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309282/
https://www.ncbi.nlm.nih.gov/pubmed/30595311
http://dx.doi.org/10.1016/j.ihj.2018.06.016
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