ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH(High) Melanoma-Initiating Cells

5-Nitrofurans are antibiotic pro-drugs that have potential as cancer therapeutics. Here, we show that 5-nitrofurans can be bio-activated by aldehyde dehydrogenase (ALDH) 1A1/1A3 enzymes that are highly expressed in a subpopulation of cancer-initiating (stem) cells. We discover that the 5-nitrofuran,...

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Detalles Bibliográficos
Autores principales: Sarvi, Sana, Crispin, Richard, Lu, Yuting, Zeng, Lifan, Hurley, Thomas D., Houston, Douglas R., von Kriegsheim, Alex, Chen, Che-Hong, Mochly-Rosen, Daria, Ranzani, Marco, Mathers, Marie E., Xu, Xiaowei, Xu, Wei, Adams, David J., Carragher, Neil O., Fujita, Mayumi, Schuchter, Lynn, Unciti-Broceta, Asier, Brunton, Valerie G., Patton, E. Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309505/
https://www.ncbi.nlm.nih.gov/pubmed/30293938
http://dx.doi.org/10.1016/j.chembiol.2018.09.005

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