Cargando…

Accounting for proximal variants improves neoantigen prediction

Recent efforts to design personalized cancer immunotherapies use predicted neoantigens, but most neoantigen prediction strategies do not consider proximal (nearby) variants that alter the peptide sequence and may influence neoantigen binding. We evaluated somatic variants from 430 tumors to understa...

Descripción completa

Detalles Bibliográficos
Autores principales: Hundal, Jasreet, Kiwala, Susanna, Feng, Yang-Yang, Liu, Connor J., Govindan, Ramaswamy, Chapman, William C., Uppaluri, Ravindra, Swamidass, S Joshua, Griffith, Obi L., Mardis, Elaine R., Griffith, Malachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309579/
https://www.ncbi.nlm.nih.gov/pubmed/30510237
http://dx.doi.org/10.1038/s41588-018-0283-9

Ejemplares similares