Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

Extensive tracts of the mammalian genome that lack protein-coding function are still transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length restricted, and non-polyadenylated, how their expression is distinguished from protein-coding genes remains enigmatic. Surpr...

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Detalles Bibliográficos
Autores principales: Nojima, Takayuki, Tellier, Michael, Foxwell, Jonathan, Ribeiro de Almeida, Claudia, Tan-Wong, Sue Mei, Dhir, Somdutta, Dujardin, Gwendal, Dhir, Ashish, Murphy, Shona, Proudfoot, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309921/
https://www.ncbi.nlm.nih.gov/pubmed/30449723
http://dx.doi.org/10.1016/j.molcel.2018.10.011

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