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Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

RNase H2 has two distinct functions: initiation of the ribonucleotide excision repair (RER) pathway by cleaving ribonucleotides (rNMPs) incorporated during DNA replication and processing the RNA portion of an R-loop formed during transcription. An RNase H2 mutant lacking RER activity but supporting...

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Detalles Bibliográficos
Autores principales:	Uehara, Ryo, Cerritelli, Susana M., Hasin, Naushaba, Sakhuja, Kiran, London, Mariya, Iranzo, Jaime, Chon, Hyongi, Grinberg, Alexander, Crouch, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309994/ https://www.ncbi.nlm.nih.gov/pubmed/30380406 http://dx.doi.org/10.1016/j.celrep.2018.10.019

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