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Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation

The aim of this study was a comparison of aortic valve calcium score (AVCS) between patients with hypercholesterolemia and genetic diagnosis of familial hypercholesterolemia with low-density lipoprotein receptor gene mutation (LDLR-M group), versus patients with hypercholesterolemia without LDLR gen...

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Autores principales: Gałąska, Rafal, Kulawiak-Gałąska, Dorota, Chmara, Magdalena, Chlebus, Krzysztof, Studniarek, Michał, Fijałkowski, Marcin, Wasąg, Bartosz, Rynkiewicz, Andrzej, Gruchała, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310281/
https://www.ncbi.nlm.nih.gov/pubmed/30592719
http://dx.doi.org/10.1371/journal.pone.0209229
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author Gałąska, Rafal
Kulawiak-Gałąska, Dorota
Chmara, Magdalena
Chlebus, Krzysztof
Studniarek, Michał
Fijałkowski, Marcin
Wasąg, Bartosz
Rynkiewicz, Andrzej
Gruchała, Marcin
author_facet Gałąska, Rafal
Kulawiak-Gałąska, Dorota
Chmara, Magdalena
Chlebus, Krzysztof
Studniarek, Michał
Fijałkowski, Marcin
Wasąg, Bartosz
Rynkiewicz, Andrzej
Gruchała, Marcin
author_sort Gałąska, Rafal
collection PubMed
description The aim of this study was a comparison of aortic valve calcium score (AVCS) between patients with hypercholesterolemia and genetic diagnosis of familial hypercholesterolemia with low-density lipoprotein receptor gene mutation (LDLR-M group), versus patients with hypercholesterolemia without LDLR gene mutation (LDLR-WT group). A total of 72 LDLR-M patients and 50 LDLR-WT patients were enrolled in the study and underwent CT as a part of an assessment of coronary calcium scoring. AVCS was determined and compared between the two patient groups. AVCS was significantly higher in the LDLR-M group in comparison to the LDLR-WT group (13.8 ± 37.9 vs. 0.94 ± 3.1, p = 0.03). The Yates' chi-squared test for independence revealed that LDLR mutation and AVCS were significantly dependable (Chi^2 = 6.106, p = 0.013). The LDLR mutation was a strong predictor of a high AVCS (OR 7.83, 95% CI 2.08–29.50, p = 0.002) on multivariate regression analysis. Among the traditional risk factors, age (odds ratio 1.12, 95% CI 1.05–1.18, p<0.001) and SBP (OR 1.04, 95% CI 1.00–1.07, p = 0.045) were also significant for high result of AVCS. An assessment of computed tomography calcium scores showed that LDLR-M patients have increased AVCS in comparison to those with LDLR-WT. In addition, LDLR mutation can be considered as an independent risk factor of having high AVSC even after adjustment for risk factors including cholesterol levels. This may result from the associated process connected with the regulatory role of LDLR in evolution of aortic valve calcifications.
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spelling pubmed-63102812019-01-08 Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation Gałąska, Rafal Kulawiak-Gałąska, Dorota Chmara, Magdalena Chlebus, Krzysztof Studniarek, Michał Fijałkowski, Marcin Wasąg, Bartosz Rynkiewicz, Andrzej Gruchała, Marcin PLoS One Research Article The aim of this study was a comparison of aortic valve calcium score (AVCS) between patients with hypercholesterolemia and genetic diagnosis of familial hypercholesterolemia with low-density lipoprotein receptor gene mutation (LDLR-M group), versus patients with hypercholesterolemia without LDLR gene mutation (LDLR-WT group). A total of 72 LDLR-M patients and 50 LDLR-WT patients were enrolled in the study and underwent CT as a part of an assessment of coronary calcium scoring. AVCS was determined and compared between the two patient groups. AVCS was significantly higher in the LDLR-M group in comparison to the LDLR-WT group (13.8 ± 37.9 vs. 0.94 ± 3.1, p = 0.03). The Yates' chi-squared test for independence revealed that LDLR mutation and AVCS were significantly dependable (Chi^2 = 6.106, p = 0.013). The LDLR mutation was a strong predictor of a high AVCS (OR 7.83, 95% CI 2.08–29.50, p = 0.002) on multivariate regression analysis. Among the traditional risk factors, age (odds ratio 1.12, 95% CI 1.05–1.18, p<0.001) and SBP (OR 1.04, 95% CI 1.00–1.07, p = 0.045) were also significant for high result of AVCS. An assessment of computed tomography calcium scores showed that LDLR-M patients have increased AVCS in comparison to those with LDLR-WT. In addition, LDLR mutation can be considered as an independent risk factor of having high AVSC even after adjustment for risk factors including cholesterol levels. This may result from the associated process connected with the regulatory role of LDLR in evolution of aortic valve calcifications. Public Library of Science 2018-12-28 /pmc/articles/PMC6310281/ /pubmed/30592719 http://dx.doi.org/10.1371/journal.pone.0209229 Text en © 2018 Gałąska et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gałąska, Rafal
Kulawiak-Gałąska, Dorota
Chmara, Magdalena
Chlebus, Krzysztof
Studniarek, Michał
Fijałkowski, Marcin
Wasąg, Bartosz
Rynkiewicz, Andrzej
Gruchała, Marcin
Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title_full Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title_fullStr Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title_full_unstemmed Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title_short Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
title_sort aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310281/
https://www.ncbi.nlm.nih.gov/pubmed/30592719
http://dx.doi.org/10.1371/journal.pone.0209229
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