The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome towar...

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Detalles Bibliográficos
Autores principales: Hodson, Nathan, Philp, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310455/
https://www.ncbi.nlm.nih.gov/pubmed/30334852
http://dx.doi.org/10.1249/JES.0000000000000173
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author Hodson, Nathan
Philp, Andrew
author_facet Hodson, Nathan
Philp, Andrew
author_sort Hodson, Nathan
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description The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
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spelling pubmed-63104552019-01-14 The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control Hodson, Nathan Philp, Andrew Exerc Sport Sci Rev Articles The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation. Lippincott Williams & Wilkins 2019-01 2018-12-14 /pmc/articles/PMC6310455/ /pubmed/30334852 http://dx.doi.org/10.1249/JES.0000000000000173 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Hodson, Nathan
Philp, Andrew
The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title_full The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title_fullStr The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title_full_unstemmed The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title_short The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
title_sort importance of mtor trafficking for human skeletal muscle translational control
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310455/
https://www.ncbi.nlm.nih.gov/pubmed/30334852
http://dx.doi.org/10.1249/JES.0000000000000173
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