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The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT

Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on no...

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Autores principales: Goldenberg, Limor, Saliba, Walid, Hayeq, Hashem, Hasadia, Rabea, Zeina, Abdel-Rauf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310554/
https://www.ncbi.nlm.nih.gov/pubmed/30544382
http://dx.doi.org/10.1097/MD.0000000000013233
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author Goldenberg, Limor
Saliba, Walid
Hayeq, Hashem
Hasadia, Rabea
Zeina, Abdel-Rauf
author_facet Goldenberg, Limor
Saliba, Walid
Hayeq, Hashem
Hasadia, Rabea
Zeina, Abdel-Rauf
author_sort Goldenberg, Limor
collection PubMed
description Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on non-enhanced computed tomography (CT). We retrospectively included 492 patients who underwent non-enhanced CT scans during workup for clinically suspected renal colic. All scans were reviewed for abdominal aorta calcification, liver attenuation, and thickness of visceral and subcutaneous fat. Multivariate general linear regression models were used to assess the association between abdominal aorta calcium score and adiposity measures. In the model that included only adiposity measures; visceral fat thickness had statistically significant direct association with abdominal aorta calcium score (B = 67.1, P <.001), whereas subcutaneous pelvic fat thickness had a significant inverse association with abdominal aorta calcium score (B = −22.34, P <.001). Only the association of subcutaneous pelvic fat thickness with abdominal aorta calcium score remained statistically significant when controlling for age, sex, smoking, hypertension, diabetes mellitus, and hyperlipidemia (B = −21.23, P <.001). In this model, the association of visceral fat remained statistically significant in females (B = 84.28, P = .001) but not in males (B = 0.47, P = .973). Visceral fat thickness and subcutaneous pelvic fat thickness were found to have opposing associations with abdominal aorta calcium score. This suggests that while visceral fat may have a lipotoxic effect on aortic atherosclerotic processes, subcutaneous pelvic fat may have a protective role in these processes.
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spelling pubmed-63105542019-01-14 The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT Goldenberg, Limor Saliba, Walid Hayeq, Hashem Hasadia, Rabea Zeina, Abdel-Rauf Medicine (Baltimore) Research Article Cardiovascular (CV) morbidity, atherosclerosis, and obesity are all targets of clinical concern and vast research, as is the association between them. Aim of this study is to assess the impact of adipose tissue (including visceral and subcutaneous fat) on abdominal aorta calcification measured on non-enhanced computed tomography (CT). We retrospectively included 492 patients who underwent non-enhanced CT scans during workup for clinically suspected renal colic. All scans were reviewed for abdominal aorta calcification, liver attenuation, and thickness of visceral and subcutaneous fat. Multivariate general linear regression models were used to assess the association between abdominal aorta calcium score and adiposity measures. In the model that included only adiposity measures; visceral fat thickness had statistically significant direct association with abdominal aorta calcium score (B = 67.1, P <.001), whereas subcutaneous pelvic fat thickness had a significant inverse association with abdominal aorta calcium score (B = −22.34, P <.001). Only the association of subcutaneous pelvic fat thickness with abdominal aorta calcium score remained statistically significant when controlling for age, sex, smoking, hypertension, diabetes mellitus, and hyperlipidemia (B = −21.23, P <.001). In this model, the association of visceral fat remained statistically significant in females (B = 84.28, P = .001) but not in males (B = 0.47, P = .973). Visceral fat thickness and subcutaneous pelvic fat thickness were found to have opposing associations with abdominal aorta calcium score. This suggests that while visceral fat may have a lipotoxic effect on aortic atherosclerotic processes, subcutaneous pelvic fat may have a protective role in these processes. Wolters Kluwer Health 2018-12-10 /pmc/articles/PMC6310554/ /pubmed/30544382 http://dx.doi.org/10.1097/MD.0000000000013233 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Goldenberg, Limor
Saliba, Walid
Hayeq, Hashem
Hasadia, Rabea
Zeina, Abdel-Rauf
The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title_full The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title_fullStr The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title_full_unstemmed The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title_short The impact of abdominal fat on abdominal aorta calcification measured on non-enhanced CT
title_sort impact of abdominal fat on abdominal aorta calcification measured on non-enhanced ct
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310554/
https://www.ncbi.nlm.nih.gov/pubmed/30544382
http://dx.doi.org/10.1097/MD.0000000000013233
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