Cargando…
Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis
BACKGROUND: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. METHODS: PubMed, Embase, Scopus, Cochrane Central Register of Controlled T...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310584/ https://www.ncbi.nlm.nih.gov/pubmed/30544429 http://dx.doi.org/10.1097/MD.0000000000013453 |
_version_ | 1783383466732158976 |
---|---|
author | Feng, Rongfang Wang, Peng Gao, Chenhao Yang, Jianbo Chen, Zixiao Yang, Yaoyao Jiao, Jiawei Li, Mengmeng Fu, Bo Li, Ling Zhang, Zhenxiang Wang, Shiguang |
author_facet | Feng, Rongfang Wang, Peng Gao, Chenhao Yang, Jianbo Chen, Zixiao Yang, Yaoyao Jiao, Jiawei Li, Mengmeng Fu, Bo Li, Ling Zhang, Zhenxiang Wang, Shiguang |
author_sort | Feng, Rongfang |
collection | PubMed |
description | BACKGROUND: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. METHODS: PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, Clinical trials. gov, Wan fang Data (Chinese), VIP (Chinese), and CNKI (Chinese) were retrieved from inception to April 2017. Randomized controlled trials (RCTs) and self-controlled trials (SCTs) were recruited, which met the inclusion criteria in our study. The depression rating scores, the incidence of PSD, activities of daily living (ADL), neurological impairment scores, and adverse effects were assessed. RESULTS: Around 11 studies were recruited in our work, including 1258 participants. For trials enrolled, the results were depicted: the reduction of depression rating scores was significant in sertraline groups (WMD −6.38; 95% CI −8.63 to −4.14; P < .00001); the incidence of PSD was significantly lower in sertraline groups (RR 0.48; 95%CI 0.35–0.67; P < .0001); there was obvious improvement of ADL (WMD 11.48; 95% CI 4.18–18.78; P = .002 <0.05) and neurological impairment (WMD −3.44; 95% CI −6.66 to −0.21; P = .04 <0.05); no significant difference between sertraline and control groups in the morbidity of adverse events (RR 0.94; 95% CI 0.83–1.06; P = .33 >0.05). However, in sensitivity analyses, the conclusions of the reduction of depression rating scores and the improvement of ADL were altered. CONCLUSIONS: The study suggests that sertraline has a potentially protective role compared with control groups and demonstrates sertraline is safe. However, the reduction of depression rating scores and the improvement of ADL should be considered carefully. |
format | Online Article Text |
id | pubmed-6310584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63105842019-01-14 Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis Feng, Rongfang Wang, Peng Gao, Chenhao Yang, Jianbo Chen, Zixiao Yang, Yaoyao Jiao, Jiawei Li, Mengmeng Fu, Bo Li, Ling Zhang, Zhenxiang Wang, Shiguang Medicine (Baltimore) Research Article BACKGROUND: Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent. METHODS: PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, Clinical trials. gov, Wan fang Data (Chinese), VIP (Chinese), and CNKI (Chinese) were retrieved from inception to April 2017. Randomized controlled trials (RCTs) and self-controlled trials (SCTs) were recruited, which met the inclusion criteria in our study. The depression rating scores, the incidence of PSD, activities of daily living (ADL), neurological impairment scores, and adverse effects were assessed. RESULTS: Around 11 studies were recruited in our work, including 1258 participants. For trials enrolled, the results were depicted: the reduction of depression rating scores was significant in sertraline groups (WMD −6.38; 95% CI −8.63 to −4.14; P < .00001); the incidence of PSD was significantly lower in sertraline groups (RR 0.48; 95%CI 0.35–0.67; P < .0001); there was obvious improvement of ADL (WMD 11.48; 95% CI 4.18–18.78; P = .002 <0.05) and neurological impairment (WMD −3.44; 95% CI −6.66 to −0.21; P = .04 <0.05); no significant difference between sertraline and control groups in the morbidity of adverse events (RR 0.94; 95% CI 0.83–1.06; P = .33 >0.05). However, in sensitivity analyses, the conclusions of the reduction of depression rating scores and the improvement of ADL were altered. CONCLUSIONS: The study suggests that sertraline has a potentially protective role compared with control groups and demonstrates sertraline is safe. However, the reduction of depression rating scores and the improvement of ADL should be considered carefully. Wolters Kluwer Health 2018-12-10 /pmc/articles/PMC6310584/ /pubmed/30544429 http://dx.doi.org/10.1097/MD.0000000000013453 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Feng, Rongfang Wang, Peng Gao, Chenhao Yang, Jianbo Chen, Zixiao Yang, Yaoyao Jiao, Jiawei Li, Mengmeng Fu, Bo Li, Ling Zhang, Zhenxiang Wang, Shiguang Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title | Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title_full | Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title_fullStr | Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title_full_unstemmed | Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title_short | Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis |
title_sort | effect of sertraline in the treatment and prevention of poststroke depression: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310584/ https://www.ncbi.nlm.nih.gov/pubmed/30544429 http://dx.doi.org/10.1097/MD.0000000000013453 |
work_keys_str_mv | AT fengrongfang effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT wangpeng effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT gaochenhao effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT yangjianbo effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT chenzixiao effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT yangyaoyao effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT jiaojiawei effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT limengmeng effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT fubo effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT liling effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT zhangzhenxiang effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis AT wangshiguang effectofsertralineinthetreatmentandpreventionofpoststrokedepressionametaanalysis |