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Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review

Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An (18)F-fluoro...

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Autores principales: Bourcier, Kevin, Fermeaux, Veronique, Leobon, Sophie, Deluche, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310724/
https://www.ncbi.nlm.nih.gov/pubmed/30607169
http://dx.doi.org/10.4048/jbc.2018.21.e55
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author Bourcier, Kevin
Fermeaux, Veronique
Leobon, Sophie
Deluche, Elise
author_facet Bourcier, Kevin
Fermeaux, Veronique
Leobon, Sophie
Deluche, Elise
author_sort Bourcier, Kevin
collection PubMed
description Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An (18)F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indicated lobular breast carcinoma (positive GATA3, loss of E-cadherin expression) metastatic to the thyroid with a luminal profile. Immunohistochemical analysis was negative for primary thyroid or parathyroid carcinoma. To our knowledge, this is the first report of a patient presenting a metastatic invasive lobular carcinoma in the thyroid and lymph nodes without a prior diagnosis of breast cancer.
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spelling pubmed-63107242019-01-03 Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review Bourcier, Kevin Fermeaux, Veronique Leobon, Sophie Deluche, Elise J Breast Cancer Case Report Metastasis from primary cancer to the thyroid is uncommon in breast cancer. Here we present a case of lobular breast carcinoma that metastasized to the thyroid. A 54-year-old woman without symptoms was admitted to our institution for staging of the lymph node above the left clavicle. An (18)F-fluoro-deoxy-D-glucose positron emission tomography scan was performed for staging, and low uptakes were observed in the left supraclavicular and cervical lymph nodes. High uptake was seen in the posterior and lower left lobe of the thyroid. Histologic findings indicated lobular breast carcinoma (positive GATA3, loss of E-cadherin expression) metastatic to the thyroid with a luminal profile. Immunohistochemical analysis was negative for primary thyroid or parathyroid carcinoma. To our knowledge, this is the first report of a patient presenting a metastatic invasive lobular carcinoma in the thyroid and lymph nodes without a prior diagnosis of breast cancer. Korean Breast Cancer Society 2018-12 2018-11-27 /pmc/articles/PMC6310724/ /pubmed/30607169 http://dx.doi.org/10.4048/jbc.2018.21.e55 Text en © 2018 Korean Breast Cancer Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bourcier, Kevin
Fermeaux, Veronique
Leobon, Sophie
Deluche, Elise
Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title_full Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title_fullStr Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title_full_unstemmed Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title_short Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review
title_sort lobular breast carcinoma metastasis to the thyroid gland: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310724/
https://www.ncbi.nlm.nih.gov/pubmed/30607169
http://dx.doi.org/10.4048/jbc.2018.21.e55
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