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Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease

OBJECTIVE: The study aimed to explore the relationship of the telomere length with type 2 diabetes mellitus (DM) among patients with ischemic heart disease (IHD). METHOD: This 2-year cross-sectional study included 130 male patients diagnosed with IHD through echocardiography and coronary angiography...

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Autores principales: Piplani, Shobhit, Alemao, Nadezdha Niyarah, Prabhu, Madhav, Ambar, Sameer, Chugh, Yashasvi, Chugh, Sanjay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310747/
https://www.ncbi.nlm.nih.gov/pubmed/30595252
http://dx.doi.org/10.1016/j.ihj.2018.09.007
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author Piplani, Shobhit
Alemao, Nadezdha Niyarah
Prabhu, Madhav
Ambar, Sameer
Chugh, Yashasvi
Chugh, Sanjay Kumar
author_facet Piplani, Shobhit
Alemao, Nadezdha Niyarah
Prabhu, Madhav
Ambar, Sameer
Chugh, Yashasvi
Chugh, Sanjay Kumar
author_sort Piplani, Shobhit
collection PubMed
description OBJECTIVE: The study aimed to explore the relationship of the telomere length with type 2 diabetes mellitus (DM) among patients with ischemic heart disease (IHD). METHOD: This 2-year cross-sectional study included 130 male patients diagnosed with IHD through echocardiography and coronary angiography, wherein consecutive IHD patients with type 2 DM (65) and without type 2 DM (65) were selected. Baseline characteristics including age, gender, body mass index, and blood pressure were recorded. Laboratory investigations such as random blood sugar (RBS), fasting lipid profile, serum creatinine, and serum urea levels were measured. Quantitative real-time polymerase chain reaction was used for the measurement of the telomere length. The logistic regression analysis was used to predict the relationship of the telomere length with age and type 2 DM among patients with IHD. RESULTS: All the patients in the study were men, and most of them (diabetics = 22; nondiabetics = 20) were aged between 56 and 65 years. Age (p = 0.003), telomere length (p < 0.001), RBS (p < 0.001), serum creatinine (p < 0013), and serum urea (p < 0.04) were significantly higher in the diabetic subset than in the nondiabetic subset. No significant relationship was observed between age and the telomere length (p = 0.813); however, the mean telomere length was significantly high among the patients with type 2 DM than those without type 2 DM (p = 0.005). The logistic regression analysis showed that the telomere shortening (p = 0.00019) and RBS (p < 0.0001) were the significant risk factors for type 2 DM in patients with IHD. CONCLUSION: The telomere shortening was significantly correlated with type 2 DM among the patients with IHD. However, multicentric studies with larger samples are required to validate the current observation.
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spelling pubmed-63107472019-12-01 Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease Piplani, Shobhit Alemao, Nadezdha Niyarah Prabhu, Madhav Ambar, Sameer Chugh, Yashasvi Chugh, Sanjay Kumar Indian Heart J Clinical and Preventive Cardiology OBJECTIVE: The study aimed to explore the relationship of the telomere length with type 2 diabetes mellitus (DM) among patients with ischemic heart disease (IHD). METHOD: This 2-year cross-sectional study included 130 male patients diagnosed with IHD through echocardiography and coronary angiography, wherein consecutive IHD patients with type 2 DM (65) and without type 2 DM (65) were selected. Baseline characteristics including age, gender, body mass index, and blood pressure were recorded. Laboratory investigations such as random blood sugar (RBS), fasting lipid profile, serum creatinine, and serum urea levels were measured. Quantitative real-time polymerase chain reaction was used for the measurement of the telomere length. The logistic regression analysis was used to predict the relationship of the telomere length with age and type 2 DM among patients with IHD. RESULTS: All the patients in the study were men, and most of them (diabetics = 22; nondiabetics = 20) were aged between 56 and 65 years. Age (p = 0.003), telomere length (p < 0.001), RBS (p < 0.001), serum creatinine (p < 0013), and serum urea (p < 0.04) were significantly higher in the diabetic subset than in the nondiabetic subset. No significant relationship was observed between age and the telomere length (p = 0.813); however, the mean telomere length was significantly high among the patients with type 2 DM than those without type 2 DM (p = 0.005). The logistic regression analysis showed that the telomere shortening (p = 0.00019) and RBS (p < 0.0001) were the significant risk factors for type 2 DM in patients with IHD. CONCLUSION: The telomere shortening was significantly correlated with type 2 DM among the patients with IHD. However, multicentric studies with larger samples are required to validate the current observation. Elsevier 2018-12 2018-09-28 /pmc/articles/PMC6310747/ /pubmed/30595252 http://dx.doi.org/10.1016/j.ihj.2018.09.007 Text en © 2018 Cardiological Society of India. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical and Preventive Cardiology
Piplani, Shobhit
Alemao, Nadezdha Niyarah
Prabhu, Madhav
Ambar, Sameer
Chugh, Yashasvi
Chugh, Sanjay Kumar
Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title_full Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title_fullStr Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title_full_unstemmed Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title_short Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
title_sort correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease
topic Clinical and Preventive Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310747/
https://www.ncbi.nlm.nih.gov/pubmed/30595252
http://dx.doi.org/10.1016/j.ihj.2018.09.007
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