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Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury
The aim of this study is to evaluate if a gel of bacterial cellulose gel can revert the loss of anal resting pressure after anorectum sphincter injury in rat model, elected as a model to simulate fecal incontinence. Thirty-nine animals were equally divided into three groups: Control (CG), Sphincter...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310775/ https://www.ncbi.nlm.nih.gov/pubmed/30603694 http://dx.doi.org/10.1016/j.heliyon.2018.e01058 |
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author | Cavalcante, Aline Ribeiro Teixeira Lima, Rodrigo Pontes de Souza, Veridiana Sales Barbosa de Pinto, Flávia Cristina Morone Campos Júnior, Olavio Silva, Jaiurte Gomes Martins da Albuquerque, Amanda Vasconcelos de Aguiar, José Lamartine de Andrade |
author_facet | Cavalcante, Aline Ribeiro Teixeira Lima, Rodrigo Pontes de Souza, Veridiana Sales Barbosa de Pinto, Flávia Cristina Morone Campos Júnior, Olavio Silva, Jaiurte Gomes Martins da Albuquerque, Amanda Vasconcelos de Aguiar, José Lamartine de Andrade |
author_sort | Cavalcante, Aline Ribeiro Teixeira |
collection | PubMed |
description | The aim of this study is to evaluate if a gel of bacterial cellulose gel can revert the loss of anal resting pressure after anorectum sphincter injury in rat model, elected as a model to simulate fecal incontinence. Thirty-nine animals were equally divided into three groups: Control (CG), Sphincter injury plus Saline injection (SG) and Sphincter injury plus Bacterial Cellulose Gel injection (BCG). Anal pressure at rest was assessed for all animal in the three groups using anorectum manometry. Saline and Gel groups were subject to anorectum sphincter injury to reduce the anal pressure at rest. Fifteen days later Saline or Gel was injected into the anorectum, according to their groups. Sixty days later first manometry, the anorectum of all animals were removed and processed histologically. The CG group showed maintenance of their mean anorectal resting pressure levels; SG presented a fall in their mean anorectal resting pressure. The BCG presented a significant elevation of the mean anorectal resting pressure levels, surpassing the pressure of CG. The gel of bacterial cellulose remained at the injection site and was neovascularized, colonized by fibroblasts and dense conjunctive tissue. Those data suggest that BC can be used as a future filling agent treatment for fecal incontinence in clinical trial protocols. |
format | Online Article Text |
id | pubmed-6310775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63107752019-01-02 Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury Cavalcante, Aline Ribeiro Teixeira Lima, Rodrigo Pontes de Souza, Veridiana Sales Barbosa de Pinto, Flávia Cristina Morone Campos Júnior, Olavio Silva, Jaiurte Gomes Martins da Albuquerque, Amanda Vasconcelos de Aguiar, José Lamartine de Andrade Heliyon Article The aim of this study is to evaluate if a gel of bacterial cellulose gel can revert the loss of anal resting pressure after anorectum sphincter injury in rat model, elected as a model to simulate fecal incontinence. Thirty-nine animals were equally divided into three groups: Control (CG), Sphincter injury plus Saline injection (SG) and Sphincter injury plus Bacterial Cellulose Gel injection (BCG). Anal pressure at rest was assessed for all animal in the three groups using anorectum manometry. Saline and Gel groups were subject to anorectum sphincter injury to reduce the anal pressure at rest. Fifteen days later Saline or Gel was injected into the anorectum, according to their groups. Sixty days later first manometry, the anorectum of all animals were removed and processed histologically. The CG group showed maintenance of their mean anorectal resting pressure levels; SG presented a fall in their mean anorectal resting pressure. The BCG presented a significant elevation of the mean anorectal resting pressure levels, surpassing the pressure of CG. The gel of bacterial cellulose remained at the injection site and was neovascularized, colonized by fibroblasts and dense conjunctive tissue. Those data suggest that BC can be used as a future filling agent treatment for fecal incontinence in clinical trial protocols. Elsevier 2018-12-27 /pmc/articles/PMC6310775/ /pubmed/30603694 http://dx.doi.org/10.1016/j.heliyon.2018.e01058 Text en © 2018 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Cavalcante, Aline Ribeiro Teixeira Lima, Rodrigo Pontes de Souza, Veridiana Sales Barbosa de Pinto, Flávia Cristina Morone Campos Júnior, Olavio Silva, Jaiurte Gomes Martins da Albuquerque, Amanda Vasconcelos de Aguiar, José Lamartine de Andrade Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title | Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title_full | Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title_fullStr | Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title_full_unstemmed | Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title_short | Effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
title_sort | effects of bacterial cellulose gel on the anorectal resting pressures in rats submitted to anal sphincter injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310775/ https://www.ncbi.nlm.nih.gov/pubmed/30603694 http://dx.doi.org/10.1016/j.heliyon.2018.e01058 |
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