Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. While cellular metabolism tightly regulates T cell activation and function, metabolic reprogramming in aged T cells has not been thoroughly studied. Here, we repo...

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Detalles Bibliográficos
Autores principales: Ron-Harel, Noga, Notarangelo, Giulia, Ghergurovich, Jonathan M., Paulo, Joao A., Sage, Peter T., Santos, Daniel, Satterstrom, F. Kyle, Gygi, Steven P., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310842/
https://www.ncbi.nlm.nih.gov/pubmed/30530686
http://dx.doi.org/10.1073/pnas.1804149115

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