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Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice
The suprachiasmatic nucleus (SCN) is the principal circadian clock of mammals, coordinating daily rhythms of physiology and behavior. Circadian timing pivots around self-sustaining transcriptional–translational negative feedback loops (TTFLs), whereby CLOCK and BMAL1 drive the expression of the nega...
Autores principales: | Maywood, Elizabeth S., Elliott, Thomas S., Patton, Andrew P., Krogager, Toke P., Chesham, Johanna E., Ernst, Russell J., Beránek, Václav, Brancaccio, Marco, Chin, Jason W., Hastings, Michael H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310849/ https://www.ncbi.nlm.nih.gov/pubmed/30487216 http://dx.doi.org/10.1073/pnas.1811438115 |
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