Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy

Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association with the HLA DQB1*06:02/DQA1*01:02 (98% vs. 25%) heterodimer (DQ0602), T cell receptors (TCR) and other immune loci suggest autoimmunity but autoantigens are unknown. Onset is seasonal and associated with influe...

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Detalles Bibliográficos
Autores principales: Luo, Guo, Ambati, Aditya, Lin, Ling, Bonvalet, Mélodie, Partinen, Markku, Ji, Xuhuai, Maecker, Holden Terry, Mignot, Emmanuel Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310865/
https://www.ncbi.nlm.nih.gov/pubmed/30541895
http://dx.doi.org/10.1073/pnas.1818150116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310865/
https://www.ncbi.nlm.nih.gov/pubmed/30541895
http://dx.doi.org/10.1073/pnas.1818150116

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