Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal u...

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Detalles Bibliográficos
Autores principales: Keizer, Ron J., ter Heine, Rob, Frymoyer, Adam, Lesko, Lawrence J., Mangat, Ranvir, Goswami, Srijib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310898/
https://www.ncbi.nlm.nih.gov/pubmed/30255663
http://dx.doi.org/10.1002/psp4.12353
Descripción
Sumario:The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.

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