Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal u...

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Detalles Bibliográficos
Autores principales: Keizer, Ron J., ter Heine, Rob, Frymoyer, Adam, Lesko, Lawrence J., Mangat, Ranvir, Goswami, Srijib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310898/
https://www.ncbi.nlm.nih.gov/pubmed/30255663
http://dx.doi.org/10.1002/psp4.12353
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author Keizer, Ron J.
ter Heine, Rob
Frymoyer, Adam
Lesko, Lawrence J.
Mangat, Ranvir
Goswami, Srijib
author_facet Keizer, Ron J.
ter Heine, Rob
Frymoyer, Adam
Lesko, Lawrence J.
Mangat, Ranvir
Goswami, Srijib
author_sort Keizer, Ron J.
collection PubMed
description The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.
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spelling pubmed-63108982019-01-03 Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities Keizer, Ron J. ter Heine, Rob Frymoyer, Adam Lesko, Lawrence J. Mangat, Ranvir Goswami, Srijib CPT Pharmacometrics Syst Pharmacol Perspectives The development of model‐informed precision dosing (MIPD) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics. John Wiley and Sons Inc. 2018-10-16 2018-12 /pmc/articles/PMC6310898/ /pubmed/30255663 http://dx.doi.org/10.1002/psp4.12353 Text en © 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Perspectives
Keizer, Ron J.
ter Heine, Rob
Frymoyer, Adam
Lesko, Lawrence J.
Mangat, Ranvir
Goswami, Srijib
Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title_full Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title_fullStr Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title_full_unstemmed Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title_short Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities
title_sort model‐informed precision dosing at the bedside: scientific challenges and opportunities
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310898/
https://www.ncbi.nlm.nih.gov/pubmed/30255663
http://dx.doi.org/10.1002/psp4.12353
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