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Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age

The striatum codes motivated behavior. Delineating age-related differences within striatal circuitry can provide insights into neural mechanisms underlying ontogenic behavioral changes and vulnerabilities to mental disorders. To this end, a dual ventral/dorsal model of striatal function was examined...

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Autores principales: Porter, James N., Roy, Amy K., Benson, Brenda, Carlisi, Christina, Collins, Paul F., Leibenluft, Ellen, Pine, Daniel S., Luciana, Monica, Ernst, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310902/
https://www.ncbi.nlm.nih.gov/pubmed/25257972
http://dx.doi.org/10.1016/j.dcn.2014.08.011
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author Porter, James N.
Roy, Amy K.
Benson, Brenda
Carlisi, Christina
Collins, Paul F.
Leibenluft, Ellen
Pine, Daniel S.
Luciana, Monica
Ernst, Monique
author_facet Porter, James N.
Roy, Amy K.
Benson, Brenda
Carlisi, Christina
Collins, Paul F.
Leibenluft, Ellen
Pine, Daniel S.
Luciana, Monica
Ernst, Monique
author_sort Porter, James N.
collection PubMed
description The striatum codes motivated behavior. Delineating age-related differences within striatal circuitry can provide insights into neural mechanisms underlying ontogenic behavioral changes and vulnerabilities to mental disorders. To this end, a dual ventral/dorsal model of striatal function was examined using resting state intrinsic functional connectivity (iFC) imaging in 106 healthy individuals, ages 9–44. Broadly, the dorsal striatum (DS) is connected to prefrontal and parietal cortices and contributes to cognitive processes; the ventral striatum (VS) is connected to medial orbitofrontal and anterior cingulate cortices, and contributes to affective valuation and motivation. Findings revealed patterns of age-related changes that differed between VS and DS iFCs. We found an age-related increase in DS iFC with posterior cingulate cortex (pCC) that stabilized after the mid-twenties, but a decrease in VS iFC with anterior insula (aIns) and dorsal anterior cingulate cortex (dACC) that persisted into mid-adulthood. These distinct developmental trajectories of VS vs. DS iFC might underlie adolescents’ unique behavioral patterns and vulnerabilities to psychopathology, and also speaks to changes in motivational networks that extend well past 25 years old.
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spelling pubmed-63109022018-12-29 Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age Porter, James N. Roy, Amy K. Benson, Brenda Carlisi, Christina Collins, Paul F. Leibenluft, Ellen Pine, Daniel S. Luciana, Monica Ernst, Monique Dev Cogn Neurosci Original Research The striatum codes motivated behavior. Delineating age-related differences within striatal circuitry can provide insights into neural mechanisms underlying ontogenic behavioral changes and vulnerabilities to mental disorders. To this end, a dual ventral/dorsal model of striatal function was examined using resting state intrinsic functional connectivity (iFC) imaging in 106 healthy individuals, ages 9–44. Broadly, the dorsal striatum (DS) is connected to prefrontal and parietal cortices and contributes to cognitive processes; the ventral striatum (VS) is connected to medial orbitofrontal and anterior cingulate cortices, and contributes to affective valuation and motivation. Findings revealed patterns of age-related changes that differed between VS and DS iFCs. We found an age-related increase in DS iFC with posterior cingulate cortex (pCC) that stabilized after the mid-twenties, but a decrease in VS iFC with anterior insula (aIns) and dorsal anterior cingulate cortex (dACC) that persisted into mid-adulthood. These distinct developmental trajectories of VS vs. DS iFC might underlie adolescents’ unique behavioral patterns and vulnerabilities to psychopathology, and also speaks to changes in motivational networks that extend well past 25 years old. Elsevier 2014-08-30 /pmc/articles/PMC6310902/ /pubmed/25257972 http://dx.doi.org/10.1016/j.dcn.2014.08.011 Text en © 2014 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Research
Porter, James N.
Roy, Amy K.
Benson, Brenda
Carlisi, Christina
Collins, Paul F.
Leibenluft, Ellen
Pine, Daniel S.
Luciana, Monica
Ernst, Monique
Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title_full Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title_fullStr Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title_full_unstemmed Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title_short Age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
title_sort age-related changes in the intrinsic functional connectivity of the human ventral vs. dorsal striatum from childhood to middle age
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310902/
https://www.ncbi.nlm.nih.gov/pubmed/25257972
http://dx.doi.org/10.1016/j.dcn.2014.08.011
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