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Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene

Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3...

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Detalles Bibliográficos
Autores principales: Hao, Jiali, Xie, Wenjie, Li, Hui, Li, Runsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310915/
https://www.ncbi.nlm.nih.gov/pubmed/30613790
http://dx.doi.org/10.1515/med-2019-0001
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author Hao, Jiali
Xie, Wenjie
Li, Hui
Li, Runsheng
author_facet Hao, Jiali
Xie, Wenjie
Li, Hui
Li, Runsheng
author_sort Hao, Jiali
collection PubMed
description Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with O(Ad).DD3.mK5 elicited strong antitumor effect.
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spelling pubmed-63109152019-01-04 Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene Hao, Jiali Xie, Wenjie Li, Hui Li, Runsheng Open Med (Wars) Research Article Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with O(Ad).DD3.mK5 elicited strong antitumor effect. De Gruyter 2018-12-24 /pmc/articles/PMC6310915/ /pubmed/30613790 http://dx.doi.org/10.1515/med-2019-0001 Text en © 2019 Jiali Hao et al. published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Research Article
Hao, Jiali
Xie, Wenjie
Li, Hui
Li, Runsheng
Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title_full Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title_fullStr Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title_full_unstemmed Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title_short Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
title_sort prostate cancer-specific of dd3-driven oncolytic virus-harboring mk5 gene
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310915/
https://www.ncbi.nlm.nih.gov/pubmed/30613790
http://dx.doi.org/10.1515/med-2019-0001
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