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Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene
Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310915/ https://www.ncbi.nlm.nih.gov/pubmed/30613790 http://dx.doi.org/10.1515/med-2019-0001 |
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author | Hao, Jiali Xie, Wenjie Li, Hui Li, Runsheng |
author_facet | Hao, Jiali Xie, Wenjie Li, Hui Li, Runsheng |
author_sort | Hao, Jiali |
collection | PubMed |
description | Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with O(Ad).DD3.mK5 elicited strong antitumor effect. |
format | Online Article Text |
id | pubmed-6310915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-63109152019-01-04 Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene Hao, Jiali Xie, Wenjie Li, Hui Li, Runsheng Open Med (Wars) Research Article Prostate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, O(Ad).DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with O(Ad).DD3.mK5 elicited strong antitumor effect. De Gruyter 2018-12-24 /pmc/articles/PMC6310915/ /pubmed/30613790 http://dx.doi.org/10.1515/med-2019-0001 Text en © 2019 Jiali Hao et al. published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Research Article Hao, Jiali Xie, Wenjie Li, Hui Li, Runsheng Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title | Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title_full | Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title_fullStr | Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title_full_unstemmed | Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title_short | Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene |
title_sort | prostate cancer-specific of dd3-driven oncolytic virus-harboring mk5 gene |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310915/ https://www.ncbi.nlm.nih.gov/pubmed/30613790 http://dx.doi.org/10.1515/med-2019-0001 |
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