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KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer

BACKGROUND: The GTPase KRas4B has been utilized as a principal target in the development of anticancer drugs. PDE6δ transports KRas4B to the plasma membrane, where it is released to activate various signaling pathways required for the initiation and maintenance of cancer. Therefore, identifying new...

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Detalles Bibliográficos
Autores principales:	Casique-Aguirre, Diana, Briseño-Díaz, Paola, García-Gutiérrez, Ponciano, la Rosa, Claudia Haydée González-de, Quintero-Barceinas, Reyna Sara, Rojo-Domínguez, Arturo, Vergara, Irene, Medina, Luis Alberto, Correa-Basurto, José, Bello, Martiniano, Hernández-Rivas, Rosaura, del RocioThompson-Bonilla, María, Vargas, Miguel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310981/ https://www.ncbi.nlm.nih.gov/pubmed/30594165 http://dx.doi.org/10.1186/s12885-018-5142-7

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