Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride

BACKGROUND: Cobalt chloride (CoCl(2)) induces chemical hypoxia through activation of hypoxia-inducible factor-1 alpha (HIF-1α). Mammalian target of rapamycin (mTOR) is a multifaceted protein capable of regulating cell growth, angiogenesis, metabolism, proliferation, and survival. In this study, we t...

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Detalles Bibliográficos
Autores principales: Zimmerman, Mary A., Biggers, Christan D., Li, P. Andy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310999/
https://www.ncbi.nlm.nih.gov/pubmed/30594149
http://dx.doi.org/10.1186/s12868-018-0482-4

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