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An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial

BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in pa...

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Autores principales: Karusheva, Yanislava, Kunstein, Lejla, Bierwagen, Alessandra, Nowotny, Bettina, Kabisch, Stefan, Groener, Jan B., Fleitmann, Ann Kristin, Herder, Christian, Pacini, Giovanni, Strassburger, Klaus, Häring, Hans-Ulrich, Nawroth, Peter P., Pfeiffer, Andreas F. H., Burkart, Volker, Müssig, Karsten, Roden, Michael, Szendroedi, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311026/
https://www.ncbi.nlm.nih.gov/pubmed/30619502
http://dx.doi.org/10.1186/s12986-018-0324-5
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author Karusheva, Yanislava
Kunstein, Lejla
Bierwagen, Alessandra
Nowotny, Bettina
Kabisch, Stefan
Groener, Jan B.
Fleitmann, Ann Kristin
Herder, Christian
Pacini, Giovanni
Strassburger, Klaus
Häring, Hans-Ulrich
Nawroth, Peter P.
Pfeiffer, Andreas F. H.
Burkart, Volker
Müssig, Karsten
Roden, Michael
Szendroedi, Julia
author_facet Karusheva, Yanislava
Kunstein, Lejla
Bierwagen, Alessandra
Nowotny, Bettina
Kabisch, Stefan
Groener, Jan B.
Fleitmann, Ann Kristin
Herder, Christian
Pacini, Giovanni
Strassburger, Klaus
Häring, Hans-Ulrich
Nawroth, Peter P.
Pfeiffer, Andreas F. H.
Burkart, Volker
Müssig, Karsten
Roden, Michael
Szendroedi, Julia
author_sort Karusheva, Yanislava
collection PubMed
description BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. CONCLUSIONS: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 – Retrospectively registered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-018-0324-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-63110262019-01-07 An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial Karusheva, Yanislava Kunstein, Lejla Bierwagen, Alessandra Nowotny, Bettina Kabisch, Stefan Groener, Jan B. Fleitmann, Ann Kristin Herder, Christian Pacini, Giovanni Strassburger, Klaus Häring, Hans-Ulrich Nawroth, Peter P. Pfeiffer, Andreas F. H. Burkart, Volker Müssig, Karsten Roden, Michael Szendroedi, Julia Nutr Metab (Lond) Research BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. CONCLUSIONS: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 – Retrospectively registered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-018-0324-5) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-29 /pmc/articles/PMC6311026/ /pubmed/30619502 http://dx.doi.org/10.1186/s12986-018-0324-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Karusheva, Yanislava
Kunstein, Lejla
Bierwagen, Alessandra
Nowotny, Bettina
Kabisch, Stefan
Groener, Jan B.
Fleitmann, Ann Kristin
Herder, Christian
Pacini, Giovanni
Strassburger, Klaus
Häring, Hans-Ulrich
Nawroth, Peter P.
Pfeiffer, Andreas F. H.
Burkart, Volker
Müssig, Karsten
Roden, Michael
Szendroedi, Julia
An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title_full An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title_fullStr An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title_full_unstemmed An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title_short An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
title_sort 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311026/
https://www.ncbi.nlm.nih.gov/pubmed/30619502
http://dx.doi.org/10.1186/s12986-018-0324-5
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