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An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in pa...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311026/ https://www.ncbi.nlm.nih.gov/pubmed/30619502 http://dx.doi.org/10.1186/s12986-018-0324-5 |
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author | Karusheva, Yanislava Kunstein, Lejla Bierwagen, Alessandra Nowotny, Bettina Kabisch, Stefan Groener, Jan B. Fleitmann, Ann Kristin Herder, Christian Pacini, Giovanni Strassburger, Klaus Häring, Hans-Ulrich Nawroth, Peter P. Pfeiffer, Andreas F. H. Burkart, Volker Müssig, Karsten Roden, Michael Szendroedi, Julia |
author_facet | Karusheva, Yanislava Kunstein, Lejla Bierwagen, Alessandra Nowotny, Bettina Kabisch, Stefan Groener, Jan B. Fleitmann, Ann Kristin Herder, Christian Pacini, Giovanni Strassburger, Klaus Häring, Hans-Ulrich Nawroth, Peter P. Pfeiffer, Andreas F. H. Burkart, Volker Müssig, Karsten Roden, Michael Szendroedi, Julia |
author_sort | Karusheva, Yanislava |
collection | PubMed |
description | BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. CONCLUSIONS: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 – Retrospectively registered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-018-0324-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6311026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63110262019-01-07 An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial Karusheva, Yanislava Kunstein, Lejla Bierwagen, Alessandra Nowotny, Bettina Kabisch, Stefan Groener, Jan B. Fleitmann, Ann Kristin Herder, Christian Pacini, Giovanni Strassburger, Klaus Häring, Hans-Ulrich Nawroth, Peter P. Pfeiffer, Andreas F. H. Burkart, Volker Müssig, Karsten Roden, Michael Szendroedi, Julia Nutr Metab (Lond) Research BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. CONCLUSIONS: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 – Retrospectively registered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12986-018-0324-5) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-29 /pmc/articles/PMC6311026/ /pubmed/30619502 http://dx.doi.org/10.1186/s12986-018-0324-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Karusheva, Yanislava Kunstein, Lejla Bierwagen, Alessandra Nowotny, Bettina Kabisch, Stefan Groener, Jan B. Fleitmann, Ann Kristin Herder, Christian Pacini, Giovanni Strassburger, Klaus Häring, Hans-Ulrich Nawroth, Peter P. Pfeiffer, Andreas F. H. Burkart, Volker Müssig, Karsten Roden, Michael Szendroedi, Julia An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title | An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title_full | An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title_fullStr | An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title_full_unstemmed | An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title_short | An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
title_sort | 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311026/ https://www.ncbi.nlm.nih.gov/pubmed/30619502 http://dx.doi.org/10.1186/s12986-018-0324-5 |
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