PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

BACKGROUND: Chronic diseases such as chagasic megaesophagus (secondary to Chagas’ disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. OBJECTIVE: We analyzed hotspot PIK3CA gene mutations in a se...

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Detalles Bibliográficos
Autores principales: Munari, Fernanda Franco, Cruvinel-Carloni, Adriana, Lacerda, Croider Franco, de Oliveira, Antônio Talvane Torres, Scapulatempo-Neto, Cristovam, da Silva, Sandra Regina Morini, Crema, Eduardo, Adad, Sheila Jorge, Rodrigues, Maria Aparecida Marchesan, Henry, Maria Aparecida Coelho Arruda, Guimarães, Denise Peixoto, Longatto-Filho, Adhemar, Reis, Rui Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311070/
https://www.ncbi.nlm.nih.gov/pubmed/30619505
http://dx.doi.org/10.1186/s13027-018-0216-3

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