Mice Lacking Glypican 4 Display Juvenile Hyperactivity and Adult Social Interaction Deficits

Glypican 4 (Gpc4) is a heparan sulfate proteoglycan that regulates glutamatergic synapse formation and function in the developing brain. Gpc4 KO mice have been shown to have decreased excitatory synapse number and less synaptic GluA1 AMPA receptors, leading to decreased synaptic transmission. Furthe...

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Detalles Bibliográficos
Autores principales: Dowling, Cari, Allen, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311356/
https://www.ncbi.nlm.nih.gov/pubmed/30598870
http://dx.doi.org/10.3233/BPL-180079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311356/
https://www.ncbi.nlm.nih.gov/pubmed/30598870
http://dx.doi.org/10.3233/BPL-180079

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