Cargando…
Mice Lacking Glypican 4 Display Juvenile Hyperactivity and Adult Social Interaction Deficits
Glypican 4 (Gpc4) is a heparan sulfate proteoglycan that regulates glutamatergic synapse formation and function in the developing brain. Gpc4 KO mice have been shown to have decreased excitatory synapse number and less synaptic GluA1 AMPA receptors, leading to decreased synaptic transmission. Furthe...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
IOS Press
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311356/ https://www.ncbi.nlm.nih.gov/pubmed/30598870 http://dx.doi.org/10.3233/BPL-180079 |