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FGF-21 levels in polyuria-polydipsia syndrome
The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared ci...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311457/ https://www.ncbi.nlm.nih.gov/pubmed/30592707 http://dx.doi.org/10.1530/EC-18-0469 |
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author | Refardt, Julie Sailer, Clara Odilia Winzeler, Bettina Betz, Matthias Johannes Chifu, Irina Schnyder, Ingeborg Fassnacht, Martin Fenske, Wiebke Christ-Crain, Mirjam |
author_facet | Refardt, Julie Sailer, Clara Odilia Winzeler, Bettina Betz, Matthias Johannes Chifu, Irina Schnyder, Ingeborg Fassnacht, Martin Fenske, Wiebke Christ-Crain, Mirjam |
author_sort | Refardt, Julie |
collection | PubMed |
description | The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared circulating FGF-21 levels in patients with primary polydipsia to patients with AVP deficiency (central diabetes insipidus) and healthy volunteers. In this prospective cohort study, we analyzed FGF-21 levels of 20 patients with primary polydipsia, 20 patients with central diabetes insipidus and 20 healthy volunteers before and after stimulation with hypertonic saline infusion targeting a plasma sodium level ≥150 mmol/L. The primary outcome was the difference in FGF-21 levels between the three groups. Baseline characteristics were similar between the groups except for patients with central diabetes insipidus being heavier. There was no difference in baseline FGF-21 levels between patients with primary polydipsia and healthy volunteers (122 pg/mL (52,277) vs 193 pg/mL (48,301), but higher levels in patients with central diabetes insipidus were observed (306 pg/mL (114,484); P = 0.037). However, this was not confirmed in a multivariate linear regression analysis after adjusting for age, sex, BMI and smoking status. Osmotic stimulation did not affect FGF-21 levels in either group (difference to baseline: primary polydipsia −23 pg/mL (−43, 22); central diabetes insipidus 17 pg/mL (−76, 88); healthy volunteers −6 pg/mL (−68, 22); P = 0.45). To conclude, FGF-21 levels are not increased in patients with primary polydipsia as compared to central diabetes insipidus or healthy volunteers. FGF-21 therefore does not seem to be causal of elevated fluid intake in these patients. |
format | Online Article Text |
id | pubmed-6311457 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63114572019-01-03 FGF-21 levels in polyuria-polydipsia syndrome Refardt, Julie Sailer, Clara Odilia Winzeler, Bettina Betz, Matthias Johannes Chifu, Irina Schnyder, Ingeborg Fassnacht, Martin Fenske, Wiebke Christ-Crain, Mirjam Endocr Connect Research The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared circulating FGF-21 levels in patients with primary polydipsia to patients with AVP deficiency (central diabetes insipidus) and healthy volunteers. In this prospective cohort study, we analyzed FGF-21 levels of 20 patients with primary polydipsia, 20 patients with central diabetes insipidus and 20 healthy volunteers before and after stimulation with hypertonic saline infusion targeting a plasma sodium level ≥150 mmol/L. The primary outcome was the difference in FGF-21 levels between the three groups. Baseline characteristics were similar between the groups except for patients with central diabetes insipidus being heavier. There was no difference in baseline FGF-21 levels between patients with primary polydipsia and healthy volunteers (122 pg/mL (52,277) vs 193 pg/mL (48,301), but higher levels in patients with central diabetes insipidus were observed (306 pg/mL (114,484); P = 0.037). However, this was not confirmed in a multivariate linear regression analysis after adjusting for age, sex, BMI and smoking status. Osmotic stimulation did not affect FGF-21 levels in either group (difference to baseline: primary polydipsia −23 pg/mL (−43, 22); central diabetes insipidus 17 pg/mL (−76, 88); healthy volunteers −6 pg/mL (−68, 22); P = 0.45). To conclude, FGF-21 levels are not increased in patients with primary polydipsia as compared to central diabetes insipidus or healthy volunteers. FGF-21 therefore does not seem to be causal of elevated fluid intake in these patients. Bioscientifica Ltd 2018-12-04 /pmc/articles/PMC6311457/ /pubmed/30592707 http://dx.doi.org/10.1530/EC-18-0469 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Refardt, Julie Sailer, Clara Odilia Winzeler, Bettina Betz, Matthias Johannes Chifu, Irina Schnyder, Ingeborg Fassnacht, Martin Fenske, Wiebke Christ-Crain, Mirjam FGF-21 levels in polyuria-polydipsia syndrome |
title | FGF-21 levels in polyuria-polydipsia syndrome |
title_full | FGF-21 levels in polyuria-polydipsia syndrome |
title_fullStr | FGF-21 levels in polyuria-polydipsia syndrome |
title_full_unstemmed | FGF-21 levels in polyuria-polydipsia syndrome |
title_short | FGF-21 levels in polyuria-polydipsia syndrome |
title_sort | fgf-21 levels in polyuria-polydipsia syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311457/ https://www.ncbi.nlm.nih.gov/pubmed/30592707 http://dx.doi.org/10.1530/EC-18-0469 |
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