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A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade
We report the case of a 34-year-old male Hispanic patient who presented with an 8-month history of polyuria and decreased libido. An evaluation revealed hypopituitarism, central diabetes insipidus, and a pituitary stalk lesion. No evidence of a neoplasm or an inflammatory/infiltrative disease was fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311725/ https://www.ncbi.nlm.nih.gov/pubmed/30647977 http://dx.doi.org/10.1155/2018/1746917 |
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author | González Bóssolo, Alex Mangual Garcia, Michelle Davila, Kyrmarie Brau, Ricardo Sanchez Ortiz, Javier Hernan Martinez, Jose |
author_facet | González Bóssolo, Alex Mangual Garcia, Michelle Davila, Kyrmarie Brau, Ricardo Sanchez Ortiz, Javier Hernan Martinez, Jose |
author_sort | González Bóssolo, Alex |
collection | PubMed |
description | We report the case of a 34-year-old male Hispanic patient who presented with an 8-month history of polyuria and decreased libido. An evaluation revealed hypopituitarism, central diabetes insipidus, and a pituitary stalk lesion. No evidence of a neoplasm or an inflammatory/infiltrative disease was found. We treated the patient conservatively with steroid therapy. However, as a result of disease progression, transsphenoidal surgery was performed to obtain tissue for a pathological analysis. Histopathology revealed an intrasellar germinoma, confirmed by immunochemistry. Due to localized disease, radiotherapy was initiated and clinical improvement was noted. This case emphasizes the importance of histopathological analysis; for many physicians, the presentation of a pituitary stalk lesion in a young male adult creates a clinical conundrum. Although the most common etiologies are an inflammatory or secondary neoplasm, the possible presence of an intrasellar neoplasm should not be ruled out. In many cases, imaging characteristics and tumor markers may aid in the diagnosis without the need of an aggressive diagnostic approach. However, in this case, histopathological analysis was the only way to make a correct diagnosis and provide adequate treatment for the patient. |
format | Online Article Text |
id | pubmed-6311725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63117252019-01-15 A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade González Bóssolo, Alex Mangual Garcia, Michelle Davila, Kyrmarie Brau, Ricardo Sanchez Ortiz, Javier Hernan Martinez, Jose Case Rep Endocrinol Case Report We report the case of a 34-year-old male Hispanic patient who presented with an 8-month history of polyuria and decreased libido. An evaluation revealed hypopituitarism, central diabetes insipidus, and a pituitary stalk lesion. No evidence of a neoplasm or an inflammatory/infiltrative disease was found. We treated the patient conservatively with steroid therapy. However, as a result of disease progression, transsphenoidal surgery was performed to obtain tissue for a pathological analysis. Histopathology revealed an intrasellar germinoma, confirmed by immunochemistry. Due to localized disease, radiotherapy was initiated and clinical improvement was noted. This case emphasizes the importance of histopathological analysis; for many physicians, the presentation of a pituitary stalk lesion in a young male adult creates a clinical conundrum. Although the most common etiologies are an inflammatory or secondary neoplasm, the possible presence of an intrasellar neoplasm should not be ruled out. In many cases, imaging characteristics and tumor markers may aid in the diagnosis without the need of an aggressive diagnostic approach. However, in this case, histopathological analysis was the only way to make a correct diagnosis and provide adequate treatment for the patient. Hindawi 2018-12-17 /pmc/articles/PMC6311725/ /pubmed/30647977 http://dx.doi.org/10.1155/2018/1746917 Text en Copyright © 2018 Alex González Bóssolo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report González Bóssolo, Alex Mangual Garcia, Michelle Davila, Kyrmarie Brau, Ricardo Sanchez Ortiz, Javier Hernan Martinez, Jose A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title | A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title_full | A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title_fullStr | A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title_full_unstemmed | A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title_short | A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade |
title_sort | rare localized pituitary stalk germinoma presenting in the third decade |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311725/ https://www.ncbi.nlm.nih.gov/pubmed/30647977 http://dx.doi.org/10.1155/2018/1746917 |
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