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Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla

BACKGROUND: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral...

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Autores principales: Ding, Lei, Xiao, Lianxiang, Lin, Xiangtao, Xiong, Chunmei, Lin, Lingbo, Chen, Shijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311737/
https://www.ncbi.nlm.nih.gov/pubmed/30647733
http://dx.doi.org/10.1155/2018/2983725
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author Ding, Lei
Xiao, Lianxiang
Lin, Xiangtao
Xiong, Chunmei
Lin, Lingbo
Chen, Shijun
author_facet Ding, Lei
Xiao, Lianxiang
Lin, Xiangtao
Xiong, Chunmei
Lin, Lingbo
Chen, Shijun
author_sort Ding, Lei
collection PubMed
description BACKGROUND: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis). MATERIAL AND METHODS: This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016. IVIM DWI (seven different b values) was performed on a Siemens 3.0-T MRI scanner. Pure molecular diffusion (D), pseudodiffusion (D(∗)), and perfusion fraction (f) in different liver segments were evaluated. RESULTS: f, D, and D(∗) were different among the liver segments (all p < 0.05), indicating heterogeneity in IVIM parameters among liver segments. f was consistently higher in Child-Turcotte-Pugh (CTP) class A compared with CTP class B + C (p < 0.01). D and D(∗) were higher in CTP class A compared with CTP class B + C (p < 0.05). In patients with mean f value of >0.29, the AUC was 0.88 (95% CI: 0.81-0.96), with 86.8% sensitivity and 81.8% specificity for predicting CTP class A from CTP class B + C. CONCLUSION: Liver IVIM could be a promising method for classifying the severity of segmental liver dysfunction of chronic viral hepatitis as evaluated by the CTP class, which provides a noninvasive alternative for evaluating segmental liver dysfunction with accurate selection of ROIs. Potentially it can be used to monitor the progression of CLD and LC in the future.
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spelling pubmed-63117372019-01-15 Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla Ding, Lei Xiao, Lianxiang Lin, Xiangtao Xiong, Chunmei Lin, Lingbo Chen, Shijun Gastroenterol Res Pract Research Article BACKGROUND: Few studies focused on the region of interest- (ROI-) related heterogeneity of liver intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI). The aim of the study was to evaluate the differences of liver IVIM parameters among liver segments in cirrhotic livers (chronic viral hepatitis). MATERIAL AND METHODS: This was a retrospective study of 82 consecutive patients with chronic liver disease who underwent MRI examination at the Jinan Infectious Diseases Hospital between January 2015 and December 2016. IVIM DWI (seven different b values) was performed on a Siemens 3.0-T MRI scanner. Pure molecular diffusion (D), pseudodiffusion (D(∗)), and perfusion fraction (f) in different liver segments were evaluated. RESULTS: f, D, and D(∗) were different among the liver segments (all p < 0.05), indicating heterogeneity in IVIM parameters among liver segments. f was consistently higher in Child-Turcotte-Pugh (CTP) class A compared with CTP class B + C (p < 0.01). D and D(∗) were higher in CTP class A compared with CTP class B + C (p < 0.05). In patients with mean f value of >0.29, the AUC was 0.88 (95% CI: 0.81-0.96), with 86.8% sensitivity and 81.8% specificity for predicting CTP class A from CTP class B + C. CONCLUSION: Liver IVIM could be a promising method for classifying the severity of segmental liver dysfunction of chronic viral hepatitis as evaluated by the CTP class, which provides a noninvasive alternative for evaluating segmental liver dysfunction with accurate selection of ROIs. Potentially it can be used to monitor the progression of CLD and LC in the future. Hindawi 2018-12-16 /pmc/articles/PMC6311737/ /pubmed/30647733 http://dx.doi.org/10.1155/2018/2983725 Text en Copyright © 2018 Lei Ding et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ding, Lei
Xiao, Lianxiang
Lin, Xiangtao
Xiong, Chunmei
Lin, Lingbo
Chen, Shijun
Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title_full Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title_fullStr Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title_full_unstemmed Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title_short Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging (DWI) in Patients with Liver Dysfunction of Chronic Viral Hepatitis: Segmental Heterogeneity and Relationship with Child-Turcotte-Pugh Class at 3 Tesla
title_sort intravoxel incoherent motion (ivim) diffusion-weighted imaging (dwi) in patients with liver dysfunction of chronic viral hepatitis: segmental heterogeneity and relationship with child-turcotte-pugh class at 3 tesla
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311737/
https://www.ncbi.nlm.nih.gov/pubmed/30647733
http://dx.doi.org/10.1155/2018/2983725
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