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Automated Detection and Segmentation of Nonmass-Enhancing Breast Tumors with Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Nonmass-enhancing (NME) lesions constitute a diagnostic challenge in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast. Computer-aided diagnosis (CAD) systems provide physicians with advanced tools for analysis, assessment, and evaluation that have a significant impact on...

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Detalles Bibliográficos
Autores principales: Illan, Ignacio Alvarez, Ramirez, Javier, Gorriz, J. M., Marino, Maria Adele, Avendano, Daly, Helbich, Thomas, Baltzer, Pascal, Pinker, Katja, Meyer-Baese, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311739/
https://www.ncbi.nlm.nih.gov/pubmed/30647551
http://dx.doi.org/10.1155/2018/5308517
Descripción
Sumario:Nonmass-enhancing (NME) lesions constitute a diagnostic challenge in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the breast. Computer-aided diagnosis (CAD) systems provide physicians with advanced tools for analysis, assessment, and evaluation that have a significant impact on the diagnostic performance. Here, we propose a new approach to address the challenge of NME lesion detection and segmentation, taking advantage of independent component analysis (ICA) to extract data-driven dynamic lesion characterizations. A set of independent sources was obtained from the DCE-MRI dataset of breast cancer patients, and the dynamic behavior of the different tissues was described by multiple dynamic curves, together with a set of eigenimages describing the scores for each voxel. A new test image is projected onto the independent source space using the unmixing matrix, and each voxel is classified by a support vector machine (SVM) that has already been trained with manually delineated data. A solution to the high false-positive rate problem is proposed by controlling the SVM hyperplane location, outperforming previously published approaches.