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Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria

Spontaneous bacterial peritonitis (SBP) is one of the most common bacterial infections in patients with liver cirrhosis and it significantly contributes to the deterioration of the prognosis and increased risk of mortality. Previous data suggested that the most common pathogens causing SBP are G-neg...

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Autores principales: Rostkowska, Karolina Anna, Szymanek-Pasternak, Anna, Simon, Krzysztof Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311748/
https://www.ncbi.nlm.nih.gov/pubmed/30603669
http://dx.doi.org/10.5114/ceh.2018.80123
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author Rostkowska, Karolina Anna
Szymanek-Pasternak, Anna
Simon, Krzysztof Adam
author_facet Rostkowska, Karolina Anna
Szymanek-Pasternak, Anna
Simon, Krzysztof Adam
author_sort Rostkowska, Karolina Anna
collection PubMed
description Spontaneous bacterial peritonitis (SBP) is one of the most common bacterial infections in patients with liver cirrhosis and it significantly contributes to the deterioration of the prognosis and increased risk of mortality. Previous data suggested that the most common pathogens causing SBP are G-negative aerobic bacteria and treatment recommended by the international guidelines (EASL, AASLD) is highly effective. In recent years, due to the widespread use of antibiotic prophylaxis and the increased frequency of hospitalization along with the use of invasive procedures in patients with cirrhosis, the involvement of Gram-positive cocci and multi-drug resistant bacteria in the etiology of SBP is increasing. This is related to the lowering of the effectiveness of the first-line therapy used so far and worsening of the prognosis, increasing in-hospital mortality. In this work we summarize current data on the characteristics of pathogens responsible for SBP in the context of currently recommended treatment regimens.
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spelling pubmed-63117482019-01-02 Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria Rostkowska, Karolina Anna Szymanek-Pasternak, Anna Simon, Krzysztof Adam Clin Exp Hepatol Review Paper Spontaneous bacterial peritonitis (SBP) is one of the most common bacterial infections in patients with liver cirrhosis and it significantly contributes to the deterioration of the prognosis and increased risk of mortality. Previous data suggested that the most common pathogens causing SBP are G-negative aerobic bacteria and treatment recommended by the international guidelines (EASL, AASLD) is highly effective. In recent years, due to the widespread use of antibiotic prophylaxis and the increased frequency of hospitalization along with the use of invasive procedures in patients with cirrhosis, the involvement of Gram-positive cocci and multi-drug resistant bacteria in the etiology of SBP is increasing. This is related to the lowering of the effectiveness of the first-line therapy used so far and worsening of the prognosis, increasing in-hospital mortality. In this work we summarize current data on the characteristics of pathogens responsible for SBP in the context of currently recommended treatment regimens. Termedia Publishing House 2018-12-03 2018-12 /pmc/articles/PMC6311748/ /pubmed/30603669 http://dx.doi.org/10.5114/ceh.2018.80123 Text en Copyright: © 2018 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Rostkowska, Karolina Anna
Szymanek-Pasternak, Anna
Simon, Krzysztof Adam
Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title_full Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title_fullStr Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title_full_unstemmed Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title_short Spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
title_sort spontaneous bacterial peritonitis – therapeutic challenges in the era of increasing drug resistance of bacteria
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311748/
https://www.ncbi.nlm.nih.gov/pubmed/30603669
http://dx.doi.org/10.5114/ceh.2018.80123
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