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Oxidative Stress in Poultry: Lessons from the Viral Infections

Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, b...

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Autores principales: Rehman, Zaib Ur, Meng, Chunchun, Sun, Yingjie, Safdar, Anum, Pasha, Riaz Hussain, Munir, Muhammad, Ding, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311761/
https://www.ncbi.nlm.nih.gov/pubmed/30647810
http://dx.doi.org/10.1155/2018/5123147
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author Rehman, Zaib Ur
Meng, Chunchun
Sun, Yingjie
Safdar, Anum
Pasha, Riaz Hussain
Munir, Muhammad
Ding, Chan
author_facet Rehman, Zaib Ur
Meng, Chunchun
Sun, Yingjie
Safdar, Anum
Pasha, Riaz Hussain
Munir, Muhammad
Ding, Chan
author_sort Rehman, Zaib Ur
collection PubMed
description Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are commonly triggered by the pathogenic viruses and are famous for their dual roles in the clearance of viruses and pathological implications. Uncontrolled production of reactive species results in oxidative stress and causes damage in proteins, lipids, DNA, and cellular structures. In this review, we describe the production of RS, their detoxification by a cellular antioxidant system, and how these RS damage the proteins, lipids, and DNA. Given the widespread importance of RS in avian viral diseases, oxidative stress pathways are of utmost importance for targeted therapeutics. Therefore, a special focus is provided on avian virus-mediated oxidative stresses. Finally, future research perspectives are discussed on the exploitation of these pathways to treat viral diseases of poultry.
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spelling pubmed-63117612019-01-15 Oxidative Stress in Poultry: Lessons from the Viral Infections Rehman, Zaib Ur Meng, Chunchun Sun, Yingjie Safdar, Anum Pasha, Riaz Hussain Munir, Muhammad Ding, Chan Oxid Med Cell Longev Review Article Reactive species (RS), generally known as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are produced during regular metabolism in the host and are required for many cellular processes such as cytokine transcription, immunomodulation, ion transport, and apoptosis. Intriguingly, both RNS and ROS are commonly triggered by the pathogenic viruses and are famous for their dual roles in the clearance of viruses and pathological implications. Uncontrolled production of reactive species results in oxidative stress and causes damage in proteins, lipids, DNA, and cellular structures. In this review, we describe the production of RS, their detoxification by a cellular antioxidant system, and how these RS damage the proteins, lipids, and DNA. Given the widespread importance of RS in avian viral diseases, oxidative stress pathways are of utmost importance for targeted therapeutics. Therefore, a special focus is provided on avian virus-mediated oxidative stresses. Finally, future research perspectives are discussed on the exploitation of these pathways to treat viral diseases of poultry. Hindawi 2018-12-10 /pmc/articles/PMC6311761/ /pubmed/30647810 http://dx.doi.org/10.1155/2018/5123147 Text en Copyright © 2018 Zaib Ur Rehman et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rehman, Zaib Ur
Meng, Chunchun
Sun, Yingjie
Safdar, Anum
Pasha, Riaz Hussain
Munir, Muhammad
Ding, Chan
Oxidative Stress in Poultry: Lessons from the Viral Infections
title Oxidative Stress in Poultry: Lessons from the Viral Infections
title_full Oxidative Stress in Poultry: Lessons from the Viral Infections
title_fullStr Oxidative Stress in Poultry: Lessons from the Viral Infections
title_full_unstemmed Oxidative Stress in Poultry: Lessons from the Viral Infections
title_short Oxidative Stress in Poultry: Lessons from the Viral Infections
title_sort oxidative stress in poultry: lessons from the viral infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311761/
https://www.ncbi.nlm.nih.gov/pubmed/30647810
http://dx.doi.org/10.1155/2018/5123147
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