Comparison of Cardiac miRNA Transcriptomes Induced by Diabetes and Rapamycin Treatment and Identification of a Rapamycin-Associated Cardiac MicroRNA Signature

Rapamycin (Rap), an inhibitor of mTORC1, reduces obesity and improves lifespan in mice. However, hyperglycemia and lipid disorders are adverse side effects in patients receiving Rap treatment. We previously reported that diabetes induces pansuppression of cardiac cytokines in Zucker obese rats (ZO-C...

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Detalles Bibliográficos
Autores principales: Belenchia, Anthony M., Gavini, Madhavi P., Toedebusch, Ryan G., DeMarco, Vincent G., Pulakat, Lakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311877/
https://www.ncbi.nlm.nih.gov/pubmed/30647817
http://dx.doi.org/10.1155/2018/8364608

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