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Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease
INTRODUCTION: Inflammatory bowel disease (IBD) is a complicated, multifunctional disorder characterized by chronic, recurring inflammation of the digestive tract. The two main types of IBD are ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study was to determine single nucleot...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311883/ https://www.ncbi.nlm.nih.gov/pubmed/30648106 http://dx.doi.org/10.1155/2018/6914346 |
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author | Dudzińska, Ewa Gryzinska, Magdalena Kocki, Janusz |
author_facet | Dudzińska, Ewa Gryzinska, Magdalena Kocki, Janusz |
author_sort | Dudzińska, Ewa |
collection | PubMed |
description | INTRODUCTION: Inflammatory bowel disease (IBD) is a complicated, multifunctional disorder characterized by chronic, recurring inflammation of the digestive tract. The two main types of IBD are ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study was to determine single nucleotide polymorphism in fragments of the genes CARD15/NOD2 and DLG5 in patients from the Lublin Voivodeship. PATIENTS AND METHODS: The study was carried out in Lublin (Poland) in 2016. 27 individuals participated in the research. The research group comprised 9 patients with a diagnosis of Crohn's disease and 9 with ulcerative colitis, aged 20 to 48, and 9 healthy volunteers. RESULTS: No SNPs were confirmed for the CARD15/NOD2 gene fragment, but a substitution (T>C) was found in the DLG5 gene in a Crohn's disease patient. CONCLUSION: Absence of extraintestinal symptoms in patients with Crohn's disease may be associated with the absence of CARD15/NOD2 SNPs. The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease. The analysis presented is a pilot study due to the small number of samples. |
format | Online Article Text |
id | pubmed-6311883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63118832019-01-15 Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease Dudzińska, Ewa Gryzinska, Magdalena Kocki, Janusz Biomed Res Int Research Article INTRODUCTION: Inflammatory bowel disease (IBD) is a complicated, multifunctional disorder characterized by chronic, recurring inflammation of the digestive tract. The two main types of IBD are ulcerative colitis (UC) and Crohn's disease (CD). The aim of the study was to determine single nucleotide polymorphism in fragments of the genes CARD15/NOD2 and DLG5 in patients from the Lublin Voivodeship. PATIENTS AND METHODS: The study was carried out in Lublin (Poland) in 2016. 27 individuals participated in the research. The research group comprised 9 patients with a diagnosis of Crohn's disease and 9 with ulcerative colitis, aged 20 to 48, and 9 healthy volunteers. RESULTS: No SNPs were confirmed for the CARD15/NOD2 gene fragment, but a substitution (T>C) was found in the DLG5 gene in a Crohn's disease patient. CONCLUSION: Absence of extraintestinal symptoms in patients with Crohn's disease may be associated with the absence of CARD15/NOD2 SNPs. The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease. The analysis presented is a pilot study due to the small number of samples. Hindawi 2018-12-17 /pmc/articles/PMC6311883/ /pubmed/30648106 http://dx.doi.org/10.1155/2018/6914346 Text en Copyright © 2018 Ewa Dudzińska et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dudzińska, Ewa Gryzinska, Magdalena Kocki, Janusz Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title | Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title_full | Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title_fullStr | Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title_full_unstemmed | Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title_short | Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease |
title_sort | single nucleotide polymorphisms in selected genes in inflammatory bowel disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311883/ https://www.ncbi.nlm.nih.gov/pubmed/30648106 http://dx.doi.org/10.1155/2018/6914346 |
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