Computational prediction of plasma protein binding of cyclic peptides from small molecule experimental data using sparse modeling techniques

BACKGROUND: Cyclic peptide-based drug discovery is attracting increasing interest owing to its potential to avoid target protein depletion. In drug discovery, it is important to maintain the biostability of a drug within the proper range. Plasma protein binding (PPB) is the most important index of b...

Descripción completa

Detalles Bibliográficos
Autores principales: Tajimi, Takashi, Wakui, Naoki, Yanagisawa, Keisuke, Yoshikawa, Yasushi, Ohue, Masahito, Akiyama, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311893/
https://www.ncbi.nlm.nih.gov/pubmed/30598072
http://dx.doi.org/10.1186/s12859-018-2529-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311893/
https://www.ncbi.nlm.nih.gov/pubmed/30598072
http://dx.doi.org/10.1186/s12859-018-2529-z

Ejemplares similares