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Computational prediction of plasma protein binding of cyclic peptides from small molecule experimental data using sparse modeling techniques
BACKGROUND: Cyclic peptide-based drug discovery is attracting increasing interest owing to its potential to avoid target protein depletion. In drug discovery, it is important to maintain the biostability of a drug within the proper range. Plasma protein binding (PPB) is the most important index of b...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311893/ https://www.ncbi.nlm.nih.gov/pubmed/30598072 http://dx.doi.org/10.1186/s12859-018-2529-z |