DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival. DOT1L expression levels we...

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Detalles Bibliográficos
Autores principales: Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Ishida, Tadao, Maruyama, Reo, Ikeda, Hiroshi, Hayashi, Toshiaki, Sasaki, Hajime, Wakasugi, Hideki, Nishiyama, Koyo, Shindo, Tetsuya, Yamamoto, Eiichiro, Kai, Masahiro, Sasaki, Yasushi, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312027/
https://www.ncbi.nlm.nih.gov/pubmed/30171029
http://dx.doi.org/10.3324/haematol.2018.191262

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