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Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial

OBJECTIVE: Text messages significantly improve uptake of infant HIV testing in clinical trial contexts. Women who were excluded from a randomized trial in Kenya were followed to create a comparison between women who were enrolled and did not receive the study SMS intervention and women who were scre...

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Autores principales: Odeny, Thomas A., Bukusi, Elizabeth A., Geng, Elvin H., Hughes, James P., Holmes, King K., McClelland, R. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312205/
https://www.ncbi.nlm.nih.gov/pubmed/30596746
http://dx.doi.org/10.1371/journal.pone.0209854
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author Odeny, Thomas A.
Bukusi, Elizabeth A.
Geng, Elvin H.
Hughes, James P.
Holmes, King K.
McClelland, R. Scott
author_facet Odeny, Thomas A.
Bukusi, Elizabeth A.
Geng, Elvin H.
Hughes, James P.
Holmes, King K.
McClelland, R. Scott
author_sort Odeny, Thomas A.
collection PubMed
description OBJECTIVE: Text messages significantly improve uptake of infant HIV testing in clinical trial contexts. Women who were excluded from a randomized trial in Kenya were followed to create a comparison between women who were enrolled and did not receive the study SMS intervention and women who were screened but not enrolled. DESIGN: Parallel-cohort randomized controlled trial analysis. METHODS: We compared time to infant HIV testing between women in three groups: the Trial SMS group, the Trial Control group, and the Comparison Cohort comprised of women who were screened but not enrolled. RESULTS: Of the 1,115 women screened, 388 (35%) were eligible for trial enrollment, and were randomized to receive either intervention text messages (Trial SMS; N = 195) or continue usual care (Trial Control; N = 193). Among 727 women not enrolled in the study (Comparison Cohort), we obtained infant HIV testing data from clinic records for 510 (70%). The cumulative probability of infant HIV testing was highest in the Trial SMS group (92.0%; 95% CI 87.5–95.3), followed by the Trial Control group (85.1%; 95% CI 79.5–89.8), and lowest among women in the Comparison Cohort (43.4%; 95% CI 39.2–47.8). CONCLUSIONS: Both the Trial SMS group and the Trial Control group were significantly more likely to have their infants tested for HIV compared to the Comparison Cohort, providing evidence of a “clinical trial effect.” This analysis suggests that SMS interventions should be implemented as an adjunct to consistent and engaged delivery of basic health services.
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spelling pubmed-63122052019-01-08 Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial Odeny, Thomas A. Bukusi, Elizabeth A. Geng, Elvin H. Hughes, James P. Holmes, King K. McClelland, R. Scott PLoS One Research Article OBJECTIVE: Text messages significantly improve uptake of infant HIV testing in clinical trial contexts. Women who were excluded from a randomized trial in Kenya were followed to create a comparison between women who were enrolled and did not receive the study SMS intervention and women who were screened but not enrolled. DESIGN: Parallel-cohort randomized controlled trial analysis. METHODS: We compared time to infant HIV testing between women in three groups: the Trial SMS group, the Trial Control group, and the Comparison Cohort comprised of women who were screened but not enrolled. RESULTS: Of the 1,115 women screened, 388 (35%) were eligible for trial enrollment, and were randomized to receive either intervention text messages (Trial SMS; N = 195) or continue usual care (Trial Control; N = 193). Among 727 women not enrolled in the study (Comparison Cohort), we obtained infant HIV testing data from clinic records for 510 (70%). The cumulative probability of infant HIV testing was highest in the Trial SMS group (92.0%; 95% CI 87.5–95.3), followed by the Trial Control group (85.1%; 95% CI 79.5–89.8), and lowest among women in the Comparison Cohort (43.4%; 95% CI 39.2–47.8). CONCLUSIONS: Both the Trial SMS group and the Trial Control group were significantly more likely to have their infants tested for HIV compared to the Comparison Cohort, providing evidence of a “clinical trial effect.” This analysis suggests that SMS interventions should be implemented as an adjunct to consistent and engaged delivery of basic health services. Public Library of Science 2018-12-31 /pmc/articles/PMC6312205/ /pubmed/30596746 http://dx.doi.org/10.1371/journal.pone.0209854 Text en © 2018 Odeny et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Odeny, Thomas A.
Bukusi, Elizabeth A.
Geng, Elvin H.
Hughes, James P.
Holmes, King K.
McClelland, R. Scott
Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title_full Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title_fullStr Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title_full_unstemmed Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title_short Participation in a clinical trial of a text messaging intervention is associated with increased infant HIV testing: A parallel-cohort randomized controlled trial
title_sort participation in a clinical trial of a text messaging intervention is associated with increased infant hiv testing: a parallel-cohort randomized controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312205/
https://www.ncbi.nlm.nih.gov/pubmed/30596746
http://dx.doi.org/10.1371/journal.pone.0209854
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