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Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations

Cystic fibrosis transmembrane conductance regulator (CFTR), the culprit behind the genetic disease cystic fibrosis (CF), is a phosphorylation-activated, but ATP-gated anion channel. Studies of human CFTR over the past two decades have provided an in-depth understanding of how CFTR works as an ion ch...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingyao, Yu, Ying-Chun, Yeh, Jiunn-Tyng, Hwang, Tzyh-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312236/ https://www.ncbi.nlm.nih.gov/pubmed/30596737 http://dx.doi.org/10.1371/journal.pone.0209862

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