Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

Although it has been known for over a decade that the inflammatory mediator NGF sensitizes pain-receptor neurons through increased trafficking of TRPV1 channels to the plasma membrane, the mechanism by which this occurs remains mysterious. NGF activates phosphoinositide 3-kinase (PI3K), the enzyme t...

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Detalles Bibliográficos
Autores principales: Stratiievska, Anastasiia, Nelson, Sara, Senning, Eric N, Lautz, Jonathan D, Smith, Stephen EP, Gordon, Sharona E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312403/
https://www.ncbi.nlm.nih.gov/pubmed/30560783
http://dx.doi.org/10.7554/eLife.38869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312403/
https://www.ncbi.nlm.nih.gov/pubmed/30560783
http://dx.doi.org/10.7554/eLife.38869

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